目的 分析吉林大学中日联谊医院特殊使用级抗菌药物的应用情况，为临床合理使用和管理此类药物提供参考。方法 运用回顾性调查方法，收集吉林大学中日联谊医院2011-2015年特殊使用级抗菌药物的应用数据，对药物的名称、规格、使用数量、销售金额、用药频度（DDDs）、日均费用（DDC）进行统计分析。结果 特殊使用级抗菌药物品种数、品规数保持基本稳定，销售金额排序前两位的分别是2011年的头孢菌素类和碳青霉烯类、2012-2015年的碳青霉烯类和单环类，DDDs分别为167 200、121 321、92 586、90 029、88 302，DDC值呈逐年下降趋势。结论 吉林大学中日联谊医院特殊使用级抗菌药物的使用基本合理，销售金额、用药频度、日均费用等指标整体下降，提示通过医院加强管理和药师的积极参与，抗菌药物临床应用专项整治活动取得成效。

Objective To analyze the application of antibacterial agents in special use level in China-Japan Union Hospital of Jilin University, and provide a reference for clinical rational use and management of these drugs. Methods Retrospective investigation method was used, and antibacterial agents in special use level application data from 2011 to 2015 were collected. Name, specifications, use quantity, sales amount, frequency (DDDs), and average daily cost (DDC) were analyzed. Results Varieties and specifications remained basically stable. Sales ranked the top two were cephalosporins and carbon alkene drugs (in 2011) and carbon alkene classes and class ring drugs (from 2012 to 2015), and DDDs were 167 200, 121 321, 92 586, 121 321, and 92 586, respectively. DDC values declined year by year. Conclusion Use of antibacterial agents in special use level in China-Japan Union Hospital of Jilin University from 2011 to 2015 is rational. Sales amount, frequency, and average daily cost indicators decline year by year. It is suggested that hospital management and pharmacist's active participation should be strengthened, and achieve better results of clinical application of antibacterial drugs special rectification activities.