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[摘要]
目的 分析湘潭市中心医院2012-2015年中药注射剂的应用情况,为临床合理使用中药注射剂提供参考。方法 收集湘潭市中心医院计算机HIS系统提供的2012-2015年全部中药注射剂的出库数据,对品种、销售金额、用药频率(DDDs)、日均费用(DDC)进行统计、排序和分析。结果 中药注射剂销售额呈逐年上升趋势。活血化瘀类品种最多,且构成比、DDC排名均靠前;抗肿瘤类增长幅度居于所有中药注射剂首位;清热利湿解表类品种数保持较稳定;益气开窍类中药注射剂的销售金额、构成比、总DDC变化幅度不大,相对较稳定。活血化淤类中药注射剂在品种数和销售金额方面均显著多于其他类;抗肿瘤类中药注射剂中,艾迪注射液增幅明显;益气开窍类中药注射剂4年内总体销售情况较稳定,醒脑静注射液销售金额增长较大;清热利湿解表类中药注射剂在销售金额上虽不能与前述3类媲美,然而热毒宁、喜炎平注射液的排序比(B/A)均在0.91~1.20,接近1.00。药品不良反应(ADR)总共68例,其中一般级有61例,严重的有7例,药品说明书未记载的新ADR有8例。结论 2012-2015年中药注射剂在湘潭市中心医院的应用越来越广,但其产生的不良反应情况不容忽视,临床应用时应提高对用药安全性的警惕,临床药师应加强对不合理用药的干预,减少不良反应的发生,共促临床合理用药。
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[Abstract]
Objective To analyze the usage of traditional Chinese medicine injection (TCMI) in Xiangtan Central Hospital from 2012 to 2015, and provide reference for clinical rational drug use. Methods Data of all TCMI from 2012 to 2015 provided by the computer HIS system in Xiangtan Central Hospital were collected, and consumption sum, DDDs, and DDC were statistically analyzed and ranked. Results The consumption sum of TCMI increased significantly year by year from 2012 to 2015. Blood-activating and stasis-dissolving drugs had more kinds, and the constituent ratio and DDC were ranked in front. The growth rate of anti tumor drugs ranked first in all TCMI. The types of clearing heat remove-dampness relieving drugs were stable. The consumption sum, constituent ratio, and DDC changes of nourishing qi and resuscitation drugs remain relatively stable. The consumption sum and types of blood-activiating and stasis-dissolving drugs were more than those of other drugs. In anti tumor drugs, Aidi Injection increased significantly. The consumption sum of nourishing qi and resuscitation drugs were stable from 2012 to 2015. The amount of sales of Xingnaojing Injection had more growth. The consumption sum of clearing heat remove-dampness relieving drugs were less than those of the above drugs, but B/A of Reduning Injection and Xiyanping Injection were from 0.91 to 1.20, close to 1.00. There were 68 adverse drug reactions (ADR) in totally caused by TCMI, with 61 cases belonged to ordinary rank, the remaining seven cases was severe, and eight cases was new. Conclusion TCMI is widely used in Xiangtan Central Hospital from 2012 to 2015. On the contrary, the adverse drug reactions caused by TCMI are more common than ever, so the supervision of clinical safety of TCMI should be improved, and it is important for clinical pharmacists to intensify intervention of non-rational drug use in order to decrease the occurrence of ADR and co-guarantee rational drug use in clinic.
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