目的 探讨磷酸铝凝胶联合兰索拉唑治疗幽门螺杆菌（Hp）阳性胃溃疡的临床疗效。方法 选取2015年10月-2016年10月在郑州市中医院接受治疗的Hp阳性胃溃疡患者82例，按照治疗方法的差别分成对照组（41例）和治疗组（41例）。对照组口服兰索拉唑口崩片，1片/次，1次/d。治疗组在对照组的基础上口服磷酸铝凝胶，1袋/次，3次/d。两组患者均连续治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者Hp清除率、临床症状评分、超敏C反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）及胃泌素水平变化。结果 治疗后，对照组和治疗组的总有效率分别为80.49%和97.56%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，两组患者腹胀、腹痛及反酸嗳气临床症状评分均较同组治疗前降低，同组比较具有统计学意义（P<0.05）；且治疗组患者临床症状评分比对照组降低的更明显，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清hs-CRP、MMP-9、胃泌素水平明显低于同组治疗前，同组比较具有统计学意义（P<0.05）；且治疗组上述指标水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者Hp清除率为90.24%，显著高于对照组的73.17%，两组比较差异有统计学意义（P<0.05）。结论 磷酸铝凝胶联合兰索拉唑治疗Hp阳性胃溃疡临床效果显著，可明显降低机体hs-CRP、MMP-9及胃泌素水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Aluminium Phosphate Gel combined with lansoprazole in treatment of helicobacter pylori (Hp) positive gastric ulcer. Methods Patients (82 cases) with Hp positive gastric ulcer in Zhengzhou Hospital of TCM from October 2015 to October 2016 were divided into control (41 cases) and treatment (41 cases) groups based on different treatments. Patients in control group were po administered with Lansoprazole Orally Disintegrating Tablets, 1 tablet/time, once daily. Patients in treatment group were po administered with Aluminium Phosphate Gel on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the Hp clearance rate, clinical symptom score, hs-CRP, MMP-9, and gastrin levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.49% and 97.56%, respectively, and there were differences between two groups (P<0.05). After treatment, clinical symptom score of abdominal distension, abdominal pain, acid regurgitation and belching in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptom score in the treatment group decreased more significantly than that in the control group, with significant difference between two groups (P<0.05). After treatment, hs-CRP, MMP-9, and gastrin level in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the Hp clearance rate in treatment group was 90.24%, which was significantly higher than that (73.17%) in the control group, and the difference was statistically significant between two groups (P<0.05). Conclusion Aluminium Phosphate Gel combined with lansoprazole has a significant clinical effect in treatment of helicobacter pylori positive gastric ulcer, can significantly decreased the hs-CRP, MMP-9 and gastrin level, which has a certain clinical application value.