目的 探讨血栓心脉宁片联合银杏达莫治疗冠心病心绞痛的临床疗效。方法 选取2015年9月-2016年9月在驻马店市中心医院进行治疗的冠心病心绞痛患者86例，随机分为对照组（43例）和治疗组（43例）。对照组患者静脉滴注银杏达莫注射液，20 mL加入生理盐水250 mL中，2次/d。治疗组在对照组的基础上口服血栓心脉宁片，2片/次，3次/d。两组患者均连续治疗4周。观察两组患者临床疗效，同时比较两组患者治疗前后血液流变学指标、临床症状积分、心绞痛发作次数和持续时间以及血清炎性因子的变化。结果 治疗后，对照组的总有效率为81.40%，显著低于治疗组的95.35%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组患者全血黏度（WBV）、血浆黏度（PV）、纤维蛋白原（FIB）和血小板黏附率（PAR）均显著降低（P<0.05），且治疗组患者比对照组降低更显著（P<0.05）。治疗后两组患者胸痛、胸闷、心悸等临床症状积分均显著降低（P<0.05），且治疗组比对照组降低更显著（P<0.05）。治疗后，两组患者心绞痛发作次数和持续时间均显著缩短（P<0.05），且与对照组相比，治疗组缩短更显著（P<0.05）。治疗后，两组患者血清C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均显著降低（P<0.05），且治疗组患者比对照组降低更明显（P<0.05）。结论 血栓心脉宁片联合银杏达莫治疗冠心病心绞痛效果显著，有利于临床症状改善，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Xueshuan Xinmaining Tablets combined with Ginkgo leaf extract and dipyridamole in treatment of coronary heart disease with angina pectoris. Methods Patients (86 cases) with coronary heart disease with angina pectoris in Zhumadian Central Hospital from September 2015 to September 2016 were randomly divided into control group (43 cases) and treatment group (43 cases). Patients in control group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection, 20 mL added into normal saline 250 mL, twice daily. Patients in treatment group were po administered with Xueshuan Xinmaining Tablets, 2 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and blood rheology index, clinical symptom scores, the frequency and duration of angina pectoris, and serum inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control was 81.40%, which was significantly lower than 95.35% in the treatment group, and there were differences between two groups (P<0.05). After treatment, WBV, PV, FIB, and PAR in two groups were significantly decreased (P<0.05). And those in the treatment group decreased more significantly than those in the control group (P<0.05). After treatment, the clinical symptom scores of chest pain, chest distension, and palpitation in two groups were significantly decreased (P<0.05) after treatment. And these scores in the treatment group decreased more significantly than those in the control group (P<0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly shortened (P<0.05). And compared with those in the control group, those in the treatment group were shortened significantly (P<0.05). Compared with those before treatment, CRP, IL-6, and TNF-α in two groups were significantly decreased (P<0.05). And these observation indexes decreased more significantly than those in the control group (P<0.05). Conclusion Xueshuan Xinmaining Tablets combined with Ginkgo leaf extract and dipyridamole has a significant clinical effect in treatment of coronary heart disease with angina pectoris, which is conducive to improving clinical symptoms, and has a certain clinical application value.