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[摘要]
目的 探讨宫炎平片联合复方甲硝唑阴道栓治疗阴道炎的临床疗效。方法 回顾性分析2015年10月-2016年8月在三门峡市中心医院妇科接受治疗的96例阴道炎患者临床资料,随机分成对照组和治疗组,每组各48例。对照组于月经干净后每晚清洁外阴后于阴道深处置入复方甲硝唑阴道栓,1粒/次,1次/d。治疗组在对照组治疗基础上口服宫炎平片,4片/次,3次/d。两组患者均连续治疗2周后进行疗效评价。观察两组的临床疗效,比较两组治疗前后临床症状积分、生活质量积分、白细胞介素2(IL-2)、IL-4、IL-10水平的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为75.00%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组临床症状积分、IL-2显著降低,生活质量积分、IL-4、IL-10显著升高,同组治疗前后差异有统计学意义(P<0.05);治疗后治疗组临床症状积分、IL-2低于对照组,生活质量积分、IL-4、IL-10高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 宫炎平片联合复方甲硝唑阴道栓治疗阴道炎具有较好的临床疗效,可明显改善患者临床症状,提高患者生活质量,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the effect of Gongyanping Tablets combined with Compound Metronidagole Vaginal Suppositories in treatment of vaginitis. Methods The clinical data of 96 patients with vaginitis who were treated in Department of Gynaecology of Sanmenxia Central Hospital from October 2015 to August 2016 were retrospectively analyzed. The patients were randomly divided into control and treatment groups, and each group had 48 cases. The patients in the control group were put Compound Metronidagole Vaginal Suppositories deep inside the vagina after cleaning the vulva every night when the menstruation was finished, 1 grain/time, once daily. The patients in the treatment group were po administered with Gongyanping Tablets on the basis of the control group, 4 tablets/time, three times daily. The patients in two groups were treated for 2 weeks. After treatment, the efficacy was evaluated, and the changes of clinical symptoms scores, life quality scores, IL-2, IL-4, and IL-10 in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 75.00% and 91.67%, respectively, and there were differences between two groups (P<0.05). After treatment, clinical symptoms scores and IL-2 in the two groups were significantly decreased, and life quality scores, IL-4, and IL-10 were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, clinical symptoms scores and IL-2 in the treatment group were lower than those in the control group, and life quality scores, IL-4, and IL-10 in the treatment group were higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Gongyanping Tablets combined with Compound Metronidagole Vaginal Suppositories has clinical curative effect in treatment of vaginitis, and can obviously improve the clinical symptoms, and also improve the life quality, which has a certain clinical application value.
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