目的 探讨复方氨基丁酸维E胶囊联合托吡酯片治疗小儿癫痫的临床疗效。方法 选取2015年5月-2016年5月在赤峰学院附属医院进行治疗的小儿癫痫患者68例，根据治疗方案的差别分为对照组（34例）和治疗组（34例）。对照组口服托吡酯片，首剂量为1～2 mg/kg，1次/d，每2周增加0.5～2 mg/kg，终剂量为8～10 mg/kg，2次/d。治疗组在对照组的基础上口服复方氨基丁酸维E胶囊，2粒/次，3次/d。两组患者均连续治疗8周。评价两组患者的临床疗效，同时比较两组患者治疗前后血清肿瘤坏死因子-α（TNF-α）、白细胞介素-2（IL-2）、神经元特异性烯醇化酶（NSE）和S100β蛋白的水平以及癫痫发作频率变化。结果 治疗后，对照组总有效率为73.53%，明显低于治疗组的91.18%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组患儿血清TNF-α、IL-2、NSE和S100β水平均明显降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组这些指标的下降程度优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿癫痫发作频率明显降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组发作频率比对照组降低更显著，两组比较差异有统计学意义（P<0.05）。结论 复方氨基丁酸维E胶囊联合托吡酯片治疗小儿癫痫效果显著，可降低癫痫发作频率及血清炎性因子水平，并对神经功能具有保护作用，具有一定的临床推广应用价值。

Objective To explore the curative effect of Compound Amino Acid and Vitamin E Capsules combined with Topiramate Tablets in treatment of pediatric epilepsy. Methods Patients (68 cases) with epilepsy in Affiliated Hospital of Chifeng University in Chifeng from May 2015 to May 2016 were divided into the control (34 cases) and treatment (34 cases) groups based on different treatment. The patients in the control group were po administered with Topiramate Tablets, the initial dosage was 1-2 mg/kg, once daily, and which was increased by 0.5-2 mg/kg every 2 weeks until 8-10 mg/kg, then twice daily. The patients in the treatment group were po administered with Compound Amino Acid and Vitamin E Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy of the two groups was evaluated, and the changes of TNF-α, IL-2, NSE, and S100β levels, and epileptic frequency in two groups were compared. Results After treatment, the clinical efficacy in the control was 73.53%, which was significant lower than that(91.18%) in the treatment group, and there were differences between two groups (P<0.05). After treatment, TNF-α, IL-2, NSE, and S100β levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And after treatment, these indicators in treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, epileptic frequency in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And epileptic frequency in the treatment group was significant lower than that in the control group, with significant difference between two groups (P<0.05). Conclusion Compound Amino Acid and Vitamin E Capsules combined with Topiramate Tablets has a significant clinical effect in treatment of pediatric epilepsy, can reduce the epileptic frequency and level of serum inflammatory factor, and has a protective effect on nerve function, which has a certain clinical application value.