目的 探讨固肾定喘丸联合盐酸氨溴索治疗老年慢性阻塞性肺疾病急性加重期的临床疗效。方法 选取2015年6月-2016年6月在葛洲坝集团中心医院进行治疗的老年慢性阻塞性肺疾病急性加重期患者82例，根据治疗方案的差别分为对照组（41例）和治疗组（41例）。对照组患者静脉滴注盐酸氨溴索注射液，30 mg加入5%葡萄糖溶液200 mL，2次/d。治疗组在对照组的基础上口服固肾定喘丸，2 g/次，3次/d。两组均连续治疗14 d。观察两组的临床疗效，同时比较两组第1秒时间肺活量（FEV₁）、用力肺活量（FVC）、FEV₁/FVC、肿瘤坏死因子α（TNF-α）、白细胞介素8（IL-8）、肺表面活性蛋白D（SP-D）、Clara细胞分泌蛋白（CC16）、降钙素原（PCT）、pH值、血氧分压（pO₂）以及动脉血二氧化碳分压（pCO₂）。结果 治疗后，对照组总有效率为80.49%，显著低于治疗组的95.12%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，两组患者pH值、pO₂均明显升高，而pCO₂明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些指标改善情况明显优于对照组，两组比较差异均具有统计学意义（P<0.05）。治疗后，两组FEV₁、FVC和FEV₁/FVC均明显升高（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组（P<0.05）。治疗后，两组患者血清SP-D、CC16、PCT、IL-8、TNF-α水平均显著降低（P<0.05）；且与对照组相比，治疗组上述指标降低更明显（P<0.05）。结论 固肾定喘丸联合盐酸氨溴索治疗老年慢性阻塞性肺疾病急性加重期效果显著，可明显改善患者肺功能，并降低机体炎性反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Gushen Dingchuan Pills combined with ambroxol hydrochloride in treatment of acute exacerbation of chronic obstructive pulmonary disease in aged patients. Methods Aged Patients (82 cases) with acute exacerbation of chronic obstructive pulmonary disease in Central Hospital of China Gezhouba (Group) Corporation from June 2015 to June 2016 were divided into control (41 cases) and treatment (41 cases) groups based on different treatment. Patients in the control group were iv administered with Ambroxol Hydrochloride Injection, 30 mg added into 5% glucose solution 200 mL, twice daily. Patients in the treatment group were po administered with Gushen Dingchuan Pills on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and FEV₁, FVC, FEV₁/FVC, TNF-α, IL-8, SP-D, CC16, PCT, pH, pO₂, and pCO₂ in two groups were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than that (95.12%) of the treatment group, and there were differences between two groups (P<0.05). After treatment, pH and pO₂ in two groups were significantly increased, but pCO₂ was decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, FEV₁, FVC, and FEV₁/FVC in two groups were significantly increased (P<0.05). And these indicators in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the levels of SP-D, CC16, PCT, IL-8, and TNF-α were significantly decreased (P<0.05). And compared with the control group, these indicators in the treatment group more significantly decreased (P<0.05). Conclusion Gushen Dingchuan Pills combined with ambroxol hydrochloride has a significant clinical effect in treatment of acute exacerbation of chronic obstructive pulmonary disease in aged patients, can obviously improve the pulmonary function, and reduce the inflammatory reaction, which has a certain clinical application value.