目的 探讨健胃愈疡片联合铝碳酸镁和奥美拉唑治疗胃溃疡的临床疗效。方法 选取2015年1月-2016年1月在重庆市人口和计划生育科学技术研究院附属医院接受治疗的胃溃疡者66例，随机分组法分为对照组和治疗组，每组各33例。对照组口服铝碳酸镁片，2片/次，3次/d；并口服艾司奥美拉唑镁肠溶片，20 mg/次，2次/d。治疗组在对照组基础上口服健胃愈疡片，4片/次，4次/d。两组患者均治疗4周。观察两组的临床疗效，比较两组的血清学指标、临床症状评分和幽门螺旋杆菌（HP）清除率的情况。结果 治疗后，对照组和治疗组的总有效率分别为81.82%、96.97%，两组比较差异有统计学意义（P<0.05）。治疗后，两组MDA、SOD和NO水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组临床症状积分均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组临床症状积分的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组HP清除率分别为58.62%、83.33%，两组比较差异有统计学意义（P<0.05）。结论 健胃愈疡片联合铝碳酸镁和奥美拉唑治疗胃溃疡具有较好的临床疗效，可明显改善患者临床症状和血清学指标，提高HP清除率，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Jianwei Yuyang Tablets combined with hydrotalcite and omeprazole in treatment of gastric ulcer. Methods Patients (66 cases) with gastric ulcer in Chongqing City Population and Family Planning Science and Technology Research Institute Affiliated Hospital from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 33 cases. Patients in the control group were po administered with Hydrotalcite Tablets, 2 tablets/time, three times daily. And patients in the control group were also po administered with Esomeprazole Magnesium Enteric-coated Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Jianwei Yuyang Tablets on the basis of the control group, 4 tablets/time, four times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes, clinical symptom scores, and HP clearance rates in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 96.97%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of MDA, SOD, and NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptom score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, HP clearance rates in the control and treatment groups were 58.62% and 83.33%, respectively, and there was difference between two groups (P<0.05). Conclusion Jianwei Yuyang Tablets combined with hydrotalcite and omeprazole has clinical curative effect in treatment of gastric ulcer, can improve clinical symptom and serological index, and increase HP clearance rate, which has a certain clinical application value.