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目的 探讨麝香保心丸联合米力农注射液治疗充血性心力衰竭的临床疗效。方法 选取2014年3月-2016年3月皖北煤电集团总医院收治的充血性心力衰竭患者84例,按照治疗方法的差别分为对照组和治疗组,每组各42例。对照组给予米力农注射液,50 μg/kg加入到5%葡萄糖溶液20 mL中,5~10 min缓慢静脉注射,而后0.5 μg/(kg·min)加入到0.9%氯化钠溶液50 mL,持续3 h泵入。治疗组在对照组基础上口服麝香保心丸,2丸/次,3次/d。两组患者均治疗14 d。观察两组的临床疗效,比较两组脑钠肽(BNP)、糖链抗原125(CA125)、左心室射血分数(LVEF)、舒张末期内径(LEDD)、每搏输出量(SV)、心输出量(CO)、心脏指数(CI)的情况。结果 治疗后,对照组和治疗组的总有效率分别为76.19%、95.24%,两组比较差异有统计学意义(P<0.05)。治疗后,两组LVEF、SV、CO和CI均明显升高,而LEDD、BNP和CA125均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 麝香保心丸联合米力农注射液治疗充血性心力衰竭具有较好的临床疗效,可明显改善患者心脏功能,升高LVEF、SV、CO和CI,降低LEDD、BNP和CA125,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Shexiang Baoxin Pills combined with Milrinone Injection in treatment of congestive heart failure. Methods Patients (84 cases) with congestive heart failure in Wanbei Coal-Electricity Group General Hospital from March 2014 to March 2016 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 42 cases. Patients in the control group were iv administered with Milrinone Injection, 50 μg/kg added into 5% glucose solution 20 mL, slow intravenous injection for 5-10 min, and then 0.5 μg/(kg·min) added into normal saline 50 mL, continuous pumping for 3 h. Patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of the control group, 2 pills/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and BNP, CA125, LVEF, LEDD, SV, CO, and CI in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.19% and 95.24%, respectively, and there was difference between two groups (P<0.05). After treatment, LVEF, SV, CO, and CI in two groups were significantly increased, but LEDD, BNP, and CA125 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shexiang Baoxin Pills combined with Milrinone Injection has clinical curative effect in treatment of congestive heart failure, can improve heart function, increase LVEF, SV, CO, and CI, and decrease LEDD, BNP, and CA125, which has a certain clinical application value.
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