目的 探讨三七通舒胶囊联合阿魏酸钠治疗急性缺血性脑血管病的疗效观察。方法 选取2015年1月-2016年1月在四川省八一康复中心治疗的急性缺血性脑血管病患者96例，随机分为对照组和治疗组，每组各48例。对照组静脉输注注射用阿魏酸钠，0.3 g加入到5%葡萄糖溶液250 mL中，1次/d。治疗组在对照组基础上口服三七通舒胶囊，1粒/次，3次/d。两组患者均治疗28 d。观察两组的临床疗效，比较两组的血液流变学指标、血管内皮功能、炎症因子、美国国立卫生研究院卒中量表（NIHSS）评分和Barthel指数（BI）评分的情况。结果 治疗后，对照组和治疗组的总有效率分别为79.17%、93.86%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血浆黏度、全血黏度、血细胞比容（HCT）和红细胞聚集指数（RF）均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组内皮素-1（ET-1）、白细胞介素-6（IL-6）、血栓素B2（TXB2）和肿瘤坏死因子-α（TNF-α）水平均显著下降，而一氧化氮（NO）水平显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组胰岛素样生长因子（IGF）均显著上升，而基质金属蛋白酶-9（MMP-9）均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组NIHSS评分均显著降低，而BI评分均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 三七通舒胶囊联合阿魏酸钠治疗急性缺血性脑血管病具有较好的临床疗效，能显著改善患者的血液流变学和血管内皮功能，降低NIHSS评分和炎症因子水平，提高BI评分，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Sanqi Tongshu Capsules combined with sodium ferulate in treatment of acute ischemic cerebrovascular disease. Methods Patients (96 cases) with acute ischemic cerebrovascular disease in Sichuan 81 Rehabilitation Center from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Sanqi Tongshu Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and blood rheology indexes, vascular endothelial function, inflammatory factors, NIHSS scores, and BI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.17% and 93.86%, respectively, and there was difference between two groups (P<0.05). After treatment, plasma viscosity, whole blood viscosity, HCT, and RF in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ET-1, IL-6, TXB2, and TNF-α in two groups were significantly decreased, but the levels of NO in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the IGF in two groups were significantly increased, but the MMP-9 in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the NIHSS scores in two groups were significantly decreased, but the BI scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Sanqi Tongshu Capsules combined with sodium ferulate has clinical curative effect in treatment of acute ischemic cerebrovascular disease, can improve blood rheology and vascular endothelial function, decrease NIHSS score and inflammatory factor, and increase BI score, which has a certain clinical application value.