目的 设计并合成安立生坦降解杂质4，6-二甲基-2-（2，2-二苯基-乙烯氧基）嘧啶。方法 以3，3-二苯基-2，3-环氧丙酸甲酯为起始原料经水解、脱羧、开环、亲核取代反应定向合成目标化合物。结果 合成目标化合物并经IR、¹H-NMR、HRMS确证其结构；HPLC归一化法测得样品质量分数为99.5%。结论 该杂质作为对照品用于安立生坦的质量研究工作。

Objective To design and synthesize 2-[(2,2-diphenylethenyl)oxy]-4,6-dimethylpyrimidine, degradation impurity of ambrisentan. Methods Methyl 3,3-diphenyl-2,3-epoxypropionate was used as starting material to synthesize the target compound by hydrolysis, decarboxylation, open-loop, and nucleophilicsubstitution reactions. Results The target compound was synthesized and characterized by IR, ¹H-NMR, HRMS data, and the purity was 99.5% by HPLC. Conclusion The impurity can be used as reference substance to study the quality of ambrisentan.

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