青藤碱是青风藤中主要的生物碱类成分。近年来，青藤碱的抗肿瘤活性受到广泛关注。实验研究表明，青藤碱可通过诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和迁移、影响肿瘤新生血管、逆转肿瘤细胞多药耐药等多途径发挥抗肿瘤作用，并能与化疗药物协同生效。通过查阅国内外相关文献报道，综述了青藤碱抗肿瘤机制的研究进展，希望为青藤碱的深入研究提供参考。

Sinomenine is a major alkaloid from Sinomenii Caulis. In recent years, the antitumor activity of sinomenine attracted more attentions. Experimental studies have showed that sinomenine could induce apoptosis of tumor cells, inhibit invasion and migration of tumor cells, influence tumor angiogenesis, reverse multi-drug resistance of tumor cells, coordinated with chemotherapy drugs and so on. This article made a summary for domestic and foreign study literatures for antitumor mechanisms of sinomenine, to expect to provide the scientific basis for the in-depth studies of sinomenine.

科技部国际科技合作项目（2010DFA31890）；中国中医科学院自主选题研究项目（ZZ2013003）