目的 探讨培美曲塞致药品药物不良反应的规律和特点，为临床合理用药提供参考。方法 检索2005年1月-2016年5月Pubmed数据库、中国期刊全文数据库（CNKI）、万方数字化期刊全文库、中文科技期刊全文数据库（维普）等数据库报道的培美曲塞致药物不良反应的文献，并进行分析和讨论。结果 培美曲塞引起的药物不良反应共41例，男性明显多于女性，年龄集中在61~70岁；非小细胞肺癌发生的药物不良反应例数最多；用药4~6 d出现药物不良反应的例数最多，占39.0%；培美曲塞引发的药物不良反应以皮肤系统和消化系统损害较为常见，构成比分别为25.4%、23.1%。结论 培美曲塞引发的药物不良反应较为常见，临床使用时应及时处理，以确保患者用药安全。

Objective To investigate the regularity and characteristics of adverse drug reaction (ADR) induced by pemetrexed, and to provide the references for the rational use of drugs in clinic. Methods ADR induced by pemetrexed in Pubmed Database, China Journal Full-text Database (CNKI), Wanfang Database, and Chinese Science and Technology Journal Full-text Database (VIP) from January 2005 to May 2016 were retrieved, and the literature involving cases were analyzed and discussed. Results A total of 41 cases reduced by pemetrexed were analyzed, in which men with ADR induced by pemetrexed were more than those of women, and the ages of patients were mainly 61-70 years old. Patients with non-small cell lung cancer had the most ADR cases. The most cases (39.0%) were found in the medication during 4-6 days. ADR induced by pemetrexed mainly were skin system (25.4%) and digestive system (23.1%). Conclusion ADR induced by pemetrexed is common in clinic. The using of pemetrexed should be treated promptly to ensure the medication safety.

天津市卫生局科技基金面上项目（2014KY05）