目的 探讨蒲地蓝口服液联合复合维生素B和维生素C治疗腹部手术后口腔溃疡的临床疗效。方法 选取天津市南开医院2014年10月-2016年5月收治的腹部手术后口腔溃疡患者110例，随机分为对照组（60例）和治疗组（50例）。对照组患者口服复合维生素B片，2片/次，3次/d；同时口服维生素C片，1片/次，3次/d。治疗组在对照组的基础上口服蒲地蓝口服液，10 mL/次，3次/d。两组患者均持续治疗14 d。评价两组患者临床疗效、疼痛指数和平均溃疡期。结果 治疗7、14 d后，治疗组患者的总有效率分别为92.00%、94.00%，分别高于同期对照组的66.67%、81.67%，两组比较差异具有统计学意义（P<0.01）。治疗7、14 d后，两组患者疼痛指数均明显下降，同组治疗前后差异具有统计学意义（P<0.05）。治疗7、14 d后，治疗组患者疼痛指数与同期对照组相比显著降低，两组比较差异具有统计学意义（P<0.05）。治疗期间对照组和治疗组的平均溃疡期分别为6.45、5.25 d，两组患者平均溃疡期比较差异具有统计学意义（P<0.05）。结论 蒲地蓝消炎口服液联合复合维生素B和维生素C治疗腹部手术后口腔溃疡疗效确切，优于单纯使用维生素治疗。

Objective To explore the clinical efficacy of Pudilan Xiaoyan Oral Liquid combined with compound vitamin B and vitamin C in treatment of oral ulcer after abdominal surgery. Methods Patients (110 cases) with oral ulcer after abdominal surgery in Tianjin Nankai Hospital from October 2014 to May 2016 were randomly divided into the control (60 cases) and treatment (50 cases) groups. The patients in the control group were po administered with Vitamin B Complex Tablets, 2 Tablets/time, three times daily. And they were po administered with Vitamin C Tablets, 1 Tablets/time, three times daily. The patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies, pain index, and average ulcer period were evaluated. Results After treatment for 7 and 14 d, the clinical efficacies in the treatment groups were 92.00% and 94.00%, respectively, which were higher than 66.67% and 81.67% of control group during the same period, and there were differences between two groups (P<0.01). After treatment for 7 and 14 d, the pain index in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment for 7 and 14 d, the pain index in the treatment group was significant lower than that in the control group, with significant difference between two groups (P<0.05). During the treatment, the average ulcer period in the control and treatment groups were 6.45 and 5.25 d, respectively, and the difference was statistically significant between two groups (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with compound vitamin B and vitamin C has definite curative effects in treatment of oral ulcer after abdominal surgery, which was better than the vitamin therapy.