目的 探讨斑蝥酸钠维生素B6联合雷替曲塞和奥沙利铂治疗晚期结直肠癌的临床疗效。方法 选取2013年4月-2016年4月在无锡市第二中医医院和盐城市第二人民医院接受治疗的晚期结直肠癌患者50例，按照治疗方法的差别分成对照组（25例）和治疗组（25例）。对照组静脉滴注注射用雷替曲塞，3 mg/m²，第1天给药，1次/3周；同时静脉滴注注射用奥沙利铂，130 mg/m²，第1天给药，1次/3周。治疗组在对照组的基础上静脉滴注斑蝥酸钠维生素B6注射液，30 mL加入5%葡萄糖注射液250 mL，1次/d。两组患者均连续治疗6周。观察两组的临床疗效，比较两组患者生存质量、血清基质金属蛋白酶-9（MMP-9）和MMP-2水平及不良反应发生情况。结果 治疗后，对照组和治疗组的客观缓解率（ORR）分别为16.00%、44.00%，临床获益率（CBR）分别为44.00%、72.00%，两组患者临床疗效比较差异有统计学意义（P<0.05）。治疗后，两组生存质量总改善率分别为64.00%、88.00%，且治疗组患者生存期较对照组显著延长，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清MMP-2、MMP-9水平均降低，同组治疗前后差异具有统计学意义（P<0.05）；且与对照组相比，治疗组上述血清学指标的降低程度更显著，两组比较差异有统计学意义（P<0.05）。结论 斑蝥酸钠维生素B6联合雷替曲塞和奥沙利铂治疗晚期结直肠癌具有很好的临床疗效，不仅能够使机体免疫力提高，还有助于改善患者生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of disodium cantharidinate and vitamin B6 combined with raltitrexed and oxaliplatin in treatment of advanced colorectal cancer. Methods Patients (50 cases) with advanced colorectal cancer in Wuxi Second Chinese Medicine Hospital and Yancheng Second People's Hospital from April 2013 to April 2016 were divided into the control (25 cases) and treatment (25 cases) groups based on different treatments. Patients in the control group were iv administered with Raltitrexed for injection on the first day, 3 mg/m², once every 3 weeks. And they were iv administered with Oxaliplatin for injection on the first day, 130 mg/m², once every 3 weeks. Patients in the treatment group were iv administered with Disodium Cantharidinate and Vitamin B6 Injection on the basis of the control group, 30 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and survival quality, serum MMP-9 and MMP-2 levels, and adverse reactions in two groups were compared. Results After treatment, the ORR in the control and treatment groups were 16.00% and 44.00%, and CBR were 44.00% and 72.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement rate of survival quality in the control and treatment groups were 64.00% and 88.00%, respectively, and survival period in the treatment group was longer than that in the control group, and the differences were statistically significant in two groups (P<0.05). After treatment, the serum MMP-2 and MMP-9 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of the serological indexes in the treatment group was more significantly than that in the control group, with significant differences between two groups (P<0.05). Conclusion Disodium cantharidinate and vitamin B6 combined with raltitrexed and oxaliplatin has a good clinical effect in treatment of advanced colorectal, can enhances the immune ability and improves the life quality, which has a certain clinical application value.