目的 探讨金葡素注射液联合奈达铂和地塞米松治疗恶性胸腔积液的临床疗效。方法 选择2013年4月-2015年4月在重庆市第十三人民医院接受治疗的恶性胸腔积液患者76例，按治疗方案的差别分为对照组和治疗组，每组各38例。对照组胸腔注入注射用奈达铂，80 mg加入到0.9%氯化钠注射液40 mL中，1次/d；同时胸腔注入地塞米松磷酸钠注射液，10 mg加入到0.9%氯化钠注射液40 mL中，1次/d。治疗组在对照组基础上胸腔注入金葡素注射液，20 mL加入到0.9%氯化钠注射液40 mL中，1次/d。两组均治疗4周。观察两组的临床疗效，比较两组生活质量的改善情况。结果 治疗后，对照组和治疗组的有效率分别为21.05%、42.11%，临床获益率分别为71.05%、89.47%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组的生活质量总改善率分别为57.89%、78.95%，两组比较差异有统计学意义（P<0.05）。两组不良反应比较差异有统计学意义（P<0.05）。结论 金葡素注射液联合奈达铂和地塞米松治疗恶性胸腔积液具有较好的临床疗效，能改善患者的生活质量，安全性较好，具有一定的临床推广应用价值。

Objective To explore clinical effect of Staphylococcal Enterotoxin C Injection combined with nedaplatin and dexamethasone in treatment of malignant pleural effusion. Methods Patients (76 cases) with malignant pleural effusion in the Thirteenth People's Hospital of Chongqing from April 2013 to April 2015 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 38 cases. Patients in the control group were pleural injection administered with Nedaplatin for injection, 80 mg added into 40 mL normal saline, once daily. And patients in the control group were also pleural injection administered with Dexamethasone Sodium Phosphate Injection, 10 mg added into normal saline 40 mL, once daily. Patients in the treatment group were pleural injection administered with Staphylococcal Enterotoxin C Injection on the basis of the control group, 20 mg added into normal saline 40 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the improvement of the quality of life in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 21.05% and 42.11%, respectively, the clinical benefit rates in the control and treatment groups were 71.05% and 89.47%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement rates of quality of life in the control and treatment groups were 57.89% and 78.95%, respectively, and there was difference between two groups (P<0.05). The adverse reactions was difference between two groups (P<0.05). Conclusion Staphylococcal Enterotoxin C Injection combined with nedaplatin and dexamethasone has clinical curative effect in treatment of malignant pleural effusion, and can improve quality of life, with good safety, which has a certain clinical application value.