目的 探讨肾舒颗粒联合头孢哌酮钠舒巴坦钠治疗慢性肾盂肾炎的临床疗效。方法 选取2015年3月-2016年3月在江油市人民医院接受治疗的慢性肾盂肾炎患者90例，随机分组法分为对照组和治疗组，每组各45例。对照组静脉滴注注射用头孢哌酮钠舒巴坦钠，2 g加入到0.9%氯化钠注射液100 mL中，2次/d。治疗组在对照组基础上口服肾舒颗粒，2袋/次，3次/d。两组患者均治疗14 d。观察两组的临床疗效，比较两组的临床症状评分和相关指标情况。结果 治疗后，对照组和治疗组的总有效率分别为82.22%、95.56%，两组比较差异有统计学意义（P<0.05）。治疗后，两组尿频、尿急、尿痛和腰痛评分均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组白蛋白（ALB）、β₂-微球蛋白（β₂-MG）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和转化生长因子-β₁（TGF-β₁）均明显下降，而免疫球蛋白A（IgA）和免疫球蛋白G（IgG）均明显上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 肾舒颗粒联合头孢哌酮钠舒巴坦钠治疗慢性肾盂肾炎具有较好的临床疗效，能改善临床症状，调节肾功能，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Shenshu Granules combined with cefoperazone sodium and sulbactam sodium in treatment of chronic pyelonephritis. Methods Patients (90 cases) with chronic pyelonephritis in Jiangyou People's Hospital from March 2013 to March 2015 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were iv administered with Cefoperazone Sodium and Sulbactam Sodium for injection, 2 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Shenshu Granules on the basis of the control group, 2 bags/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and relevant indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.22% and 95.56%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of frequent urination, urgency, dysuria, and lumbago in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, ALB, β₂-MG, NAG, and TGF-β₁ in two groups were significantly decreased, but IgA and IgG in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shenshu Granules combined with cefoperazone sodium and sulbactam sodium has clinical curative effect in treatment of chronic pyelonephritis, and can improve clinical symptoms, regulate renal function, which has a certain clinical application value.