目的 探讨蒲元和胃胶囊联合奥美拉唑和多潘立酮治疗反流性食管炎的临床疗效。方法 选取2015年2月-2016年2月在宝鸡市中医医院接受治疗的反流性食管炎患者94例，随机分为对照组和治疗组，每组各47例。对照组患者口服奥美拉唑肠溶胶囊，1粒/次，2次/d；口服多潘立酮片，1片/次，3次/d。治疗组在对照组基础上口服蒲元和胃胶囊，4粒/次，3次/d。两组患者均治疗2个月。观察两组的临床疗效，比较两组的临床症状评分和生活质量评分情况。结果 治疗后，对照组和治疗组的总有效率分别为82.98%、95.74%，两组比较差异有统计学意义（P<0.05）。治疗后，两组烧心、反酸和胸骨后疼痛评分均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组生理功能、生理职能、身体疼痛、总体健康、生命活力、社会职能、情感职能和精神健康评分均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 蒲元和胃胶囊联合奥美拉唑和多潘立酮治疗反流性食管炎具有较好的疗效，可明显改善患者的临床症状，提高患者的生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Puyuanhewei Capsules combined with omeprazole and domperidone in treatment of reflux esophagitis. Methods Patients (94 cases) with reflux esophagitis in Baoji City Chinese Medicine Hospital from February 2015 to February 2016 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Omperazole Enteric-coated Capsules, 1 grain/time, twice daily. Patients in the control group were also po administered with Domperidone Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Puyuanhewei Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and quality of life scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.98% and 95.74%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of heartburn, acid reflux, and chest pain in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of physiological function, physiological role, body ache, general health, life vigor, social function, emotional role, and mental health in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Puyuanhewei Capsules combined with omeprazole and domperidone has clinical curative effect in treatment of reflux esophagitis, and can improve clinical symptoms, enhance quality of life, which has a certain clinical application value.