目的 探讨普罗布考联合阿托伐他汀治疗大动脉粥样硬化性脑梗死临床疗效。方法 选取2013年2月-2015年2月邢台市第三医院收治的大动脉粥样硬化性脑梗死患者100例，随机分为对照组和治疗组，每组各50例。对照组睡前口服阿托伐他汀钙片，20 mg/次，1次/d。治疗组在对照组基础上口服普罗布考片，500 mg/次，2次/d。两组均治疗12周。观察两组的临床疗效，比较两组抗氧化能力、血管内皮功能和颈动脉内膜中层厚度（IMT）和斑块面积的情况。结果 治疗后，对照组和治疗组的总有效率分别为72.0%、88.0%，两组比较差异有统计学意义（P<0.05）。治疗后，两组氧化低密度脂蛋白（ox-LDL）和丙二醛（MDA）均显著下降，而超氧化物歧化酶（SOD）均显著上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组内皮素-1（ET-1）均显著下降，而一氧化氮（NO）和反应性充血后血管内径变化率（FMD）均显著上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组IMT和斑块面积均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 普罗布考联合阿托伐他汀治疗大动脉粥样硬化性脑梗死具有较好的疗效，可改善机体应激反应和血管内皮功能，减少IMT和斑块面积，具有一定的临床推广应用价值。

Objective To investigate the effect of probucol combined with atorvastatin in treatment of large artery atherosclerotic cerebral infarction. Methods Patients (100 cases) with large artery atherosclerotic cerebral infarction in Xingtai Third Hospital from February 2013 to February 2015 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets before bedtime, 20 mg/time, once daily. Patients in the treatment group were po administered with Probucol Tablets on the basis of the control group, 500 mg/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and antioxidant capacity, vascular endothelial function, IMT, and plaque area in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.0% and 88.0%, respectively, and there was difference between two groups (P<0.05). After treatment, ox-LDL and MDA in two groups were significantly decreased, but the SOD in two groups was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the ET-1 in two groups were significantly decreased, but the NO and FMD in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, IMT and plaque area in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Probucol combined with atorvastatin has clinical curative effect in treatment of large artery atherosclerotic cerebral infarction, and can improve stress response and vascular endothelial function, decrease IMT and plaque area, which has a certain clinical application value.