目的 探讨散结镇痛胶囊联合曲普瑞林治疗子宫内膜异位症的临床疗效。方法 选取2012年5月-2015年5月在西安市第四医院接受治疗的子宫内膜异位症患者90例，按照治疗方法的差别分成对照组（45例）和治疗组（45例）。对照组患者于术后第一次月经第2天肌肉注射注射用曲普瑞林，3.75 mg/次，1次/4周。治疗组在对照组的基础上口服散结镇痛胶囊，4粒/次，3次/d。两组患者均连续治疗6个月。比较两组临床疗效、CA125、乙醛脱氢酶1（ALDH1）、人类软骨糖蛋白-4（YKL-4）、前列腺素F2α（PGF2α）、白介素-6（IL-6）、IL-18及肿瘤坏死因子-α（TNF-α）、雌二醇（E2）、卵泡刺激素（FSH）和黄体生成素（LH）表达水平。结果 治疗后，对照组和治疗组总有效率分别为80.00%和95.56%，两组比较差异有统计学意义（P<0.05）。治疗后，两组CA125、ALDH1、YKL-4和PGF2α水平均较同组治疗前显著降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后，治疗组这些观察指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清E2、FSH和LH表达水平均低于同组治疗前，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后，治疗组这些观察指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组IL-6、IL-18和TNF-α表达水平均降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后，治疗组这些观察指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 散结镇痛胶囊联合曲普瑞林治疗子宫内膜异位症疗效显著，可明显改善机体雌激素水平，并降低炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacies of Sanjie Zhentong Capsules combined with triptorelin in treatment of endometriosis. Methods Children (90 cases) with endometriosis in Xi'an NO.4 Hospital from May 2012 to May 2015 were divided into control (45 cases) and treatment (45 cases) groups based on different treatment methods. Patients in the control group were im administered with Triptorelin for injection on the second day of the first menstruation after surgery, 3.75 mg/time, once every 4 weeks. Patients in the treatment group were po administered with Sanjie Zhentong Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the levels of CA125, ALDH1, YKL-4, PGF2α, IL-6, IL-18, TNF-α, E2, FSH, and LH in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.56%, respectively, and there were differences between two groups (P<0.05). After treatment, CA125, ALDH1, YKL-4, and PGF2α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of E2, FSH, and LH in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, IL-6, IL-18, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Sanjie Zhentong Capsules combined with triptorelin has a significant clinical efficacy in treatment of endometriosis, can significantly improve the estrogen level, which has a certain clinical application value.