目的 探讨甜梦口服液联合佐匹克隆治疗老年肺心病失眠的临床疗效。方法 选取2013年2月-2015年2月天津市职业病防治院收治的老年肺心病失眠患者110例，随机分为对照组（52例）和治疗组（58例）。对照组患者口服佐匹克隆片7.5 mg/次，1次/d。治疗组在对照组治疗基础上口服甜梦口服液20 mL/次，2次/d。两组均连续治疗4周。观察两组的临床疗效，同时比较两组治疗前后匹兹堡睡眠指数（PSQI）、睡眠总时间、睡眠效率、睡眠潜伏期、快动眼（REM）潜伏期、觉醒次数、觉醒总时间、pH值、二氧化碳分压（pCO₂）、氧分压（pO₂）、的变化。结果 治疗后，对照组和治疗组的总有效率分别为65.38%、87.93%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者PSQI总分、睡眠潜伏期、REM潜伏期、觉醒次数、觉醒总时间、pCO₂均显著降低，睡眠总时间、睡眠效率、pH值、pO₂、SaO₂均显著升高，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度优于对照组，两组比较差异有统计学意义（P<0.05）。结论 甜梦口服液联合佐匹克隆治疗老年肺心病失眠具有较好的临床疗效，可改善患者的睡眠质量，降低PSQI评分，具有一定的临床推广应用价值。

Objective To observe the clinical curative effect of Tianmeng Oral Solution combined with zopiclone in treatment of senile cor pulmonale insomnia. Methods Patients (110 cases) with senile cor pulmonale insomnia in Tianjin Occupational Disease Prevention and Therapeutic Hospital from February 2013 to February 2015 were randomly divided into control (52 cases) and treatment (58 cases) groupss. The patients in the control group were po administered with Zopiclone Tablets, 7.5 mg/time, once daily. The patients in the treatment group were po administered with Tianmeng Oral Solution on the basis of the control group, 20 mL/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of PSQI scores, total sleep time, sleep efficiency, sleep latency, quick eye movement (REM) incubation period, awakening times, awakening total time, pH, pCO₂, pO₂ in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 65.38% and 87.93%%, respectively, and there were differences between two groups (P<0.05). After treatment, PSQI scores, sleep latency, REM incubation period, awakening times, awakening total time, and pCO₂ were significantly reduced, and total sleep time, sleep efficiency, pH, pO₂, and SaO₂ were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Tianmeng Oral Solution combined with zopiclone has clinical curative effect in treatment of senile cor pulmonale insomnia, and can improve the sleep quality of patients, also can reduce the PSQI scores, which has a certain clinical application value.