目的 探讨丹参多酚酸治疗急性脑梗死的临床疗效。方法 选取2013年4月-2015年4月延安市人民医院收治的脑梗死患者67例，随机分为对照组（32例）和治疗组（35例）。对照组给予常规吸氧、抗血小板聚集、神经营养药物治疗，根据病情需要给予降糖、调整血压、抗感染等对症处理。治疗组在对照组基础上静脉滴注注射用丹参多酚酸盐，200 mg加入氯化钠溶液250 mL中，1次/d。两组患者持续用药14 d。观察两组的临床疗效，比较两组氧化应激、凝血指标、脑血流动力学、脑血流灌注指标、脑梗死体积、神经功能缺损（NIHSS）评分及日常生活活动量表（Barthel指数）的情况。结果 治疗后，对照组和治疗组的总有效率分别为59.38%、82.86%，两组比较差异有统计学意义（P<0.05）。治疗后，两组检测丙二醛（MDA）均明显下降，超氧化物歧化酶（SOD）明显上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组纤维蛋白原（FIB）、D-二聚体（D-D）均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组脑前动脉（ACA）、大脑中动脉（MCA）、大脑后动脉（PCA）均明显上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组脑血流量相对值（rCBF）、脑血流容积相对值（rCBV）明显上升，脑血流平均通过时间相对值（rMTT）、对比剂峰值时间相对值（rTTP）、梗死体积明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组NIHSS评分明显下降，Barthel指数明显上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 丹参多酚酸治疗急性脑梗死具有较好的临床疗效，可降低血液黏度，减轻机体氧化应激反应，改善脑血流动力学，减少脑梗死体积，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of salvianolate in treatment of acute cerebral infarction. Methods Patients (67 cases) with acute cerebral infarction in Yan'an People's Hospital from April 2013 to April 2015 were randomly divided into control group (32 cases) and treatment group (35 cases). Patients in the control group were given conventional oxygen inhalation, antiplatelet aggregation, and neurotrophic drug. And according to the needs of the disease, patients should be given symptomatic treatment including hypoglycemic, adjusting blood pressure, and anti-infection. Patients in the treatment group were iv administered with Salvianolate for injection on the basis of the control group, 200 mg added into normal saline 250 mL, once daily. After treatment, the clinical efficacies were evaluated, and oxidative stress, coagulation indexes, cerebral hemodynamics, cerebral blood flow perfusion index, cerebral infarction volume, NIHSS scores, and Barthel indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 59.38% and 82.86%, respectively, and there was difference between two groups (P<0.05). After treatment, MDA in two groups were significantly decreased, but SOD in two groups were significantly increased, significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, FIB and and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were D-D in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, ACA, MCA, and PCA in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, rCBF and rCBV in two groups were significantly increased, but rMTT and rTTP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, but Barthel indexes in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salvianolate has clinical curative effect in treatment of acute cerebral infarction, and can decrease blood viscosity, reducing oxidative stress, improve cerebral hemodynamics, reduce cerebral infarction volume, which has a certain clinical application value.