目的 探讨口炎清颗粒联合西帕依固龈液治疗鼻咽癌放射性口腔黏膜炎的临床疗效。方法 选取2014年1月-2015年10月在湖北医药学院附属东风医院肿瘤科收治的鼻咽癌放射性口腔黏膜炎患者65例，随机分为对照组（33例）和治疗组（32例）。对照组给予西帕依固龈液，3～5 mL含漱3 min，5次/d；治疗组对照组治疗基础上口服口炎清颗粒，20 g溶于200 mL温开水冲服，2次/d，直至放疗结束。观察两组患者治疗前后疼痛程度和口腔黏膜分级的变化情况。结果 治疗6、7周末，治疗组数字疼痛评分法（NRS）疼痛分级1级患者例数明显多于对照组，2～3级疼痛患者例数明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗组在治疗4～7周末口腔黏膜分级1级患者例数显著多于对照组，3～4级患者例数明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 口炎清颗粒联合西帕依固龈液治疗鼻咽癌放射性口腔黏膜炎具有较好的临床疗效，可有效降低放射性口腔黏膜损伤及疼痛程度，具有一定的临床推广应用价值。

Objective To evaluate the clinical effect of Kouyanqing Granules combined with Xipayi Mouth Rinse in treatment of nasopharyngeal carcinoma radioactive oral mucositis. Methods Patients (65 cases) with nasopharyngeal carcinoma radioactive oral mucositis in Department of Oncology of Dongfeng Hospital Affiliated to Hubei University of Medicine from January 2014 to October 2015 were randomly divided into control (33 cases) and treatment (32 cases) groups. The patients in the control group were given Xipayi Mouth Rinse, 3-5 mL for mouthwash 3 min, five times daily. The patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group until the end of radiotherapy, and 20 g dissolved in 200 mL warm water, twice daily. The changes of pain degree and classification of the oral mucosa in two groups before and after treatment were observed. Results At the weekend of sixth and seventh week, the patients in 1 grade of NRS pain were significantly more than that in the control group, patients in 2-3 grade were significantly lower than that in the control group, and there were differences between two groups (P<0.05). In the weekend of 4-7 weeks, the patients in oral mucosa1 grade of NRS pain were significantly more than that in the control group, patients in oral mucosa 3-4 grade were significantly lower than that in the control group, and there were differences between two groups (P<0.05). Conclusion Kouyanqing Granules combined with Xipayi Mouth Rinse has clinical curative effect in treatment of nasopharyngeal carcinoma radioactive oral mucositis, and can effectively reduce the degree of radioactive oral mucosa injury and pain, which has a certain clinical application value.