目的 探究胎盘多肽注射液联合甘露聚糖肽预防骨折患者术后感染的疗效观察。方法 选取2014年1月-2015年1月在陕西省核工业二一五医院接受骨折治疗的80例患者，随机分为对照组和治疗组，每组各40例。对照组患者在基础治疗上静脉滴注注射用甘露聚糖肽，10 mg加入5%葡萄糖250 mL中，1次/d。治疗组患者在对照组治疗基础上静脉滴注胎盘多肽注射液，8 mL加入生理盐水250 mL，1次/d。两组均连续治疗14 d。比较两组患者的住院时间、渗出液消失时间、感染控制时间、皮肤愈合时间、骨骼愈合时间、术后感染率等。同时比较两组患者治疗前后肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、C-反应蛋白（CRP）、白细胞计数（WBC）、CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺和NK细胞的变化情况。结果 治疗后，治疗组住院时间、渗出液消失时间、感染控制时间、皮肤愈合时间、骨骼愈合时间均显著短于对照组，治疗组术后感染率明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组TNF-α、IL-1、IL-6、CRP、WBC均显著降低，CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺、NK均显著升高，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后治疗组这些观察指标的改善程度显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 胎盘多肽注射液联合甘露聚糖肽预防骨折患者术后感染具有较好的临床疗效，可以降低骨折患者的术后感染率，增强患者的免疫力，具有一定的临床推广应用价值。

Objective To observe the clinical effects of Placenta Polypeptide Injection combined with mannatide in prevention of postoperative infection of fracture patients. Methods Patients (80 cases) with fracture in NO. 215 Hospital of Shaanxi Nuclear Industry from January 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Mannatide for injection on the basis of treatment, 10 mg added into 5% glucose solution 250 mL, once daily. The patients in the treatment group were iv administered with Placenta Polypeptide Injection on the basis of the control group, 8 mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the hospital stay time, exudates disappeared time, the infection control time, skin healing time, bone healing time, and postoperative infection rate in two groups were compared. And the changes of TNF-α, IL-1, IL-6, CRP, WBC, CD³⁺, CD⁴⁺, CD⁴⁺/CD⁸⁺ and NK in two groups before and after treatment were compared. Results After treatment, the hospital stay time, exudates disappeared time, the infection control time, skin healing time, bone healing time, and postoperative infection rate were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, TNF-α, IL-1, IL-6, CRP, and WBC were significantly increased, and CD³⁺, CD⁴⁺, CD⁴⁺/CD⁸⁺, and NK were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, those observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Placenta Polypeptide Injection combined with mannatide has clinical curative effect in prevention of postoperative infection of fracture patients, and can reduce the postoperative infection rate of patients with fracture, and enhance the immunity of patients, which has a certain clinical application value.