目的 探讨仙灵骨葆胶囊联合地奥司明治疗腰椎间盘突出症（LDH）的临床疗效。方法 选取2014年3月-2016年3月在荆州市第二人民医院接受治疗的LDH患者76例，随机分为对照组（38例）和治疗组（38例）。对照组口服地奥司明片，2片/次，3次/d。治疗组在对照组基础上口服仙灵骨葆胶囊，3粒/次，2次/d，两组患者均连续治疗4周。观察两组的临床疗效，同时比较两组治疗前后MPQ评分、ODI评分、腰椎关节活动度、ADL评分、主要症状体征评分、血清TNF-α和IL-6水平的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为84.21%、97.37%，两组比较差异有统计学意义（P<0.05）。治疗后，两组MPQ评分、ODI评分、主要症状体征评分均明显降低，而ADL评分升高，两组血清TNF-α和IL-6水平均较治疗前显著下降，腰椎关节前屈与后伸活动度均较同组治疗前明显增加，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度优于对照组，两组比较差异有统计学意义（P<0.05）。结论 仙灵骨葆胶囊联合地奥司明治疗LDH效果显著，可明显改善患者临床症状和腰椎活动度，并可降低血清炎性因子表达，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Xianling Gubao Capsules combined with diosmin in treatment of lumbar disc herniation (LDH). Methods Patients (76 cases) with LDH in The Second Hospital of Jingzhou from March 2014 to March 2016 were randomly divided into control (38 cases) and treatment (38 cases) groups. The patients in the control group were po administered with Diosmin Tables, 2 tables/time, three times daily. The patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of the control group, 3 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical effect was evaluated. MPQ scores, ODI scores, lumbar joints activities, ADL scores, main symptoms and sings scores, serum TNF-α and IL-6 levels were compared between two groups. Results After treatment, the clinical efficacies in the control and treatment groups were 84.21% and 97.37%, respectively, and there were differences between two groups (P<0.05). After treatment, MPQ scores, ODI scores, main symptoms and sings scores, serum TNF-α and IL-6 levels in two groups were significantly decreased, ADL scores, lumbar joints flexion, and extension activities were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xianling Gubao Capsules combined with Diosmin Tables has clinical curative effect in treatment of LDH, and can significantly improve the clinical symptoms and lumbar activities, also can reduce the expression of serum inflammatory factor, which has a certain clinical application value.