目的 探讨安胃疡胶囊联合四联疗法治疗难治性消化性溃疡的临床疗效。方法 选取2015年3月-2016年3月在重庆市开县人民医院接受治疗的难治性消化性溃疡患者94例，随机分为对照组和治疗组，每组各47例。对照组给予四联疗法治疗，治疗组在对照组的基础上口服安胃疡胶囊，0.4 g/次，4次/d。两组患者均连续用药4周。观察两组患者临床疗效，同时比较两组治疗前后血清一氧化氮（NO）、内皮素（ET）、血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TGF-α）水平，幽门螺杆菌（HP）清除率的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为85.11%、97.87%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，两组患者血清ET、IL-6、TGF-α水平均显著降低，而NO、VEGF水平显著升高，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组这些观察指标改善程度优于对照组，两组比较差异有具统计学意义（P<0.05）。治疗后，对照组和治疗组HP根除率分别为80.85%、95.74%，两组比较差异有统计学意义（P<0.05）。结论 安胃疡胶囊联合四联疗法治疗难治性消化性溃疡具有显著的临床疗效，可明显改善血清细胞因子水平，提高HP根除率，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Anweiyang Capsules combined with quadruple therapy in treatment of refractory peptic ulcer. Methods Patients (94 cases) with refractory peptic ulcer in the People's Hospital of Kaixian County in Chongqing from March 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 47 cases. The patients in the control group were given quadruple therapy. The patients in the treatment group were po administered with Anweiyang Capsules on the basis of the control group, 0.4 g/time, four times daily. Each groups was treated for 4 weeks. After treatment, the clinical effect was evaluated, the changes of serum NO, ET, VEGF, IL-6, TGF-α levels, and HP eradication rate in two groups were compared. Results After treatment, the clinical effect in the control and treatment groups were 85.11% and 97.87%, respectively, and there were differences between two groups (P<0.05). After treatment, serum ET, IL-6, and TGF-α level in two groups were significantly decreased, NO and VEGF levels were increased, the difference was statistically significant in the same group (P<0.05). The observation indexes in treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The HP eradication rates in the control and treatment groups were 80.85% and 95.74%, respectively, and the difference was statistically significant between two groups (P<0.05). Conclusion Anweiyang Capsules combined with quadruple therapy has the good clinical effect in treatment of refractory peptic ulcer, can significantly improve the serum cytokine levels and the HP eradication rate, which has a certain clinical application value.