目的 探讨注射用尖吻蝮蛇血凝酶联合注射用奥美拉唑钠治疗急性非静脉曲张上消化道出血的临床疗效。方法 选取2013年6月-2015年1月商洛市中心医院收治的急性非静脉曲张上消化道出血的患者94例，依据治疗方案随机分为对照组和治疗组，每组各47例。对照组静脉滴注注射用奥美拉唑钠，40 mg溶于100 mL葡萄糖溶液中，2次/d。治疗组在对照组基础上静脉推注注射用尖吻蝮蛇血凝酶，1 U溶于20 mL生理盐水中，2次/d。两组均连续治疗5 d。观察两组的临床疗效，比较两组治疗前后临床症状和血红蛋白（Hb）水平。结果 治疗后，对照组和治疗组的总有效率分别为82.90%、95.70%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组的止血时间、输血量、住院时间、再出血率明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Hb水平均明显升高，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组Hb水平的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。两组患者不良反应均较为轻微，统计学差异不明显。结论 注射用尖吻蝮蛇血凝酶联合注射用奥美拉唑钠治疗急性非静脉曲张上消化道出血具有较好的临床疗效，止血速度快，安全性高，不良反应低，值得临床推广使用。

Objective To observe the clinical effect of Haemocoagulase Agkistrodon for injection combined with Omeprazole Sodium for injection in treatment of acute nonvariceal upper gastrointestinal bleeding. Methods Patients (94 cases) with acute nonvariceal upper gastrointestinal bleeding in Shangluo Central Hospital from June 2013 to January 2015 were selected. According to the different treatment methods, the patients were randomly divided into control and treatment group, and each group had 47 cases. The patients in the control group were iv administered with Omeprazole Sodium for injection, 40 mg added into glucose solution 100 mL, twice daily. The patients in the treatment group were iv administered with Haemocoagulase Agkistrodon for injection on the basis of the control group, 1 U added into normal saline 20 mL, twice daily. The patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms and Hb levels in two groups were compared before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 82.90% and 95.70%, respectively, and there was difference between two groups (P<0.05). After treatment, bleeding time, blood transfusion, hospital stays, and rebleeding rate in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, Hb levels in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, Hb levels in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Patients in two groups had mild adverse reaction, but there was no significant difference. Conclusion Haemocoagulase Agkistrodon for injection combined with Omeprazole Sodium for injection has clinical curative effect in treatment of acute nonvariceal upper gastrointestinal bleeding, fast bleeding, high safety, and low adverse reaction,, which has a certain clinical application value.