目的 比较缬沙坦和氨氯地平治疗原发性高血压的临床疗效。方法 选取2012年12月-2015年12北京市垂杨柳医院老年病科收治的原发性高血压患者121例，随机分为缬沙坦组（n=60）和氨氯地平组（n=61）。缬沙坦组患者口服缬沙坦胶囊，1粒/次，1次/d。氨氯地平组患者口服苯磺酸氨氯地平片，1片/次，1次/d。两组均连续治疗12周。观察两组的临床疗效，同时比较两组治疗前后收缩压、舒张压、心率、总胆固醇（TC）、三酯甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、脂联素（APN）、一氧化氮（NO）、内皮素（ET）的变化情况。结果 氨氯地平组和缬沙坦组的总有效率分别为78.69%、80.00%，两组比较差异无统计学意义。治疗后，两组患者收缩压、舒张压、心率、ET均显著降低，APN、NO显著升高，同组治疗前后差异有统计学意义（P<0.05）。治疗后，缬沙坦组心率低于氨氯地平组，APN水平高于氨氯地平组，两组比较差异具有统计学意义（P<0.05）。结论 缬沙坦和氨氯地平治疗原发性高血压均具有较好的临床疗效，缬沙坦可提高患者血浆脂联素水平，改善血管内皮功能，氨氯地平对脂联素水平无显著影响。

Objective To compare clinical curative effect of valsartan and amlodipine in treatment of primary hypertension. Methods Patients (121 cases) with primary hypertension in Department of Geratology of Beijing Chuiyangliu Hospital from December 2012 to December 2015 were randomly divided into valsartan (n=60) and amlodipine (n=61) groups. The patients in valsartan group were po administered with Valsartan Capsules, 1 grain/time, once daily. The patients in amlodipine group were po administered with Amlodipine Besylate Tablets, 1 tablet/time, once daily. The patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and the change of SBP, DBP, heart rate, TC, TG, LDL-C, HDL-C, APN, NO, and ET in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in amlodipine and valsartan groups were 78.69% and 80.00%, respectively, and there was no difference between two groups. After treatment, SBP, DBP, heart rate, and ET in two groups were significantly decreased, and APN, NO were significantly increased, and the difference was statistically significant in the same group (P<0.05). The heart rate in the valsartan group was lower than that in the control group; APN was higher than that in the control group, with significant difference between two groups (P<0.05). Conclusion Valsartan and amlodipine have clinical curative effect in treatment of primary hypertension, and valsartan can improve the level of plasma adiponectin, also can improve endothelial function, but amlodipine has no significant effect on adiponectin level.