目的 探讨龙血竭胶囊联合硫辛酸和前列地尔治疗糖尿病足的临床疗效。方法 选取2015年1月-2016年1月在雄县医院接受治疗的糖尿病足患者88例，随机分为对照组和治疗组，每组各44例。对照组静脉滴注硫辛酸注射液，0.6 g加入到0.9%氯化钠溶液250 mL中，1次/d；且还静脉滴注前列地尔注射液，20 μg加入到0.9%氯化钠溶液250 mL中，1次/d。治疗组在对照组基础上口服龙血竭胶囊，4粒/次，3次/d。两组患者均治疗4周。观察两组的临床疗效，比较两组血液流变学指标、炎症指标、踝臂血压指数（ABI）、足趾皮肤温度的情况。结果 治疗后，对照组和治疗组的总有效率分别为81.82%、95.45%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的血细胞比容（HCT）、纤维蛋白原（FIB）、红细胞聚集指数（RF）及全血高切黏度（HS）均明显降低，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的降低程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、成纤维细胞生长因子2（FGF2）、血管细胞黏附分子-1（VCAM-1）均明显将低，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的降低程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者ABI及足趾皮肤温度均明显升高，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 龙血竭胶囊联合硫辛酸和前列地尔治疗糖尿病足具有较好的临床疗效，能够明显缓解患者临床症状，改善血液流变学指标及炎症指标，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Longxuejie Capsules combined with thioctic acid and alprostadil in treatment of diabetic foot. Methods Patients (88 cases) with diabetic foot in Xiongxian Hospital from January 2013 to January 2015 were randomly divided into the control and treatment groups, and each group had 44 cases. Patients in the control group were iv administered with Thioctic Acid Injection, 0.6 g added in normal saline 250 mL, once daily. And Patients in the control group were also iv administered with Alprostadil Injection, 20 μg added in normal saline 250 mL, once daily. Patients in the treatment group were po administered with Longxuejie Capsules on the basis of the control group, 4 grains/time, three times daily. After treatment, the clinical efficacies were evaluated, and blood rheology indexes, inflammation indexes, ABI, and toe skin temperature in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 95.45%, respectively, and there was difference between two groups (P<0.05). After treatment, HCT, FIB, RF, and HS in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, IL-6, TNF-α, FGF2, and VCAM-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, ABI and toe skin temperature in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Longxuejie Capsules combined with thioctic acid and alprostadil has clinical curative effect in treatment of diabetic foot, and can significantly improve clinical symptoms, blood rheology indexes, and inflammation indexes, which has a certain clinical application value.