目的 探讨醋酸去氨加压素注射液联合醋酸奥曲肽注射液治疗肝硬化合并食管胃底静脉曲张破裂出血的临床疗效。方法 选取2013年1月—2015年6月在陕西省中医医院就诊的肝硬化合并食管胃底静脉曲张破裂出血患者96例，将所有患者随机分为对照组和治疗组，每组各48例。对照组患者给予醋酸奥曲肽注射液，首先0.1 mg静脉推注5 min，随后以0.6mg溶于5%葡萄糖500 mL中，通过输液泵以50 μg/h连续静脉滴注，12 h/次。治疗组患者在对照组治疗方案的基础上静脉注射醋酸去氨加压素注射液0.3 μg/kg。两组患者均连续治疗3 d。观察两组的临床疗效，记录患者的止血时间和输血量，比较不良反应发生情况。结果 治疗后，对照组、治疗组的总有效率分别为75.00%、93.75%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者的止血时间和输血量均显著短于对照组，两组比较差异有统计学意义（P<0.01）。对照组、治疗组的不良反应发生率分别为37.50%、10.41%，两组比较差异具有统计学意义（P<0.01）。结论 醋酸去氨加压素注射液联合醋酸奥曲肽注射液治疗肝硬化合并食管胃底静脉曲张破裂出血具有较好的临床疗效，可缩短止血时间，降低不良反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Desmopressin Acetate Injection combined with Octreotide Acetate Injection in treatment of liver cirrhosis with esophageal and gastric variceal bleeding. Methods Patients (96 cases) with liver cirrhosis with esophageal and gastric variceal bleeding in Traditional Chinese Medicine Hospital of Shaanxi Province from January 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were given Octreotide Acetate Injection, 0.1 mg iv injection in 5 min firstly, then 0.6 mg Octreotide Acetate Injection added into 5% glucose 500 mL, through the infusion pump with 50 μg/h continuous iv infusion, 12 h/time. Patients in the treatment group were iv administered with Desmopressin Acetate Injection on the basis of the control group, 0.3 μg/kg. The patients in two groups were treated for 3 d. After treatment, the efficacy was evaluated, hemostatic time and volume of blood transfusion in two groups were recorded, and incidences of adverse reactions between two groups were compared. Results After treatment, the clinical efficacies of control and treatment groups were 75.00% and 93.75%, respectively, and there were differences between two groups (P<0.05). After treatment, the hemostatic time and volume of blood transfusion in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.01). The incidence of adverse reactions of control and treatment groups were 37.50% and 10.41%, respectively, and there were differences between two groups (P<0.01). Conclusion Desmopressin Acetate Injection combined with Octreotide Acetate Injection has good clinical curative effect in treatment of liver cirrhosis with esophageal and gastric variceal bleeding, can shorten hemostatic time, reduce the incidence of adverse reactions, which has a certain clinical application value.