目的 探讨仙灵骨葆胶囊联合伊班膦酸钠注射液和碳酸钙D₃治疗老年骨质疏松症的临床疗效。方法 选取2013年3月—2014年3月郫县人民医院收治的骨质疏松症患者74例，按治疗方法的不同分为对照组和治疗组，每组各37例。对照组患者静脉滴注伊班膦酸钠注射液，2 mg加入生理盐水250 mL，滴注时间≥2 h，3个月1次；同时口服碳酸钙D₃片，1片/d。治疗组在此基础上口服仙灵骨葆胶囊，2粒/次，3次/d。两组患者均治疗12个月。观察两组的临床疗效，同时比较两组治疗前后血钙（S-Ca）、血磷（S-P）、碱性磷酸酶（ALP）、骨密度（BMD）和骨钙素（BGP）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为78.38%、89.19%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者S-P、ALP均显著降低，且S-Ca升高，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组上述指标改善程度优于对照组（P<0.05）。治疗后，两组患者腰椎L2-L4 BMD、股骨颈BMD和BGP均显著升高（P<0.05）；且治疗组升高更明显，两组比较差异具有统计学意义（P<0.05）。结论 仙灵骨葆胶囊联合伊班膦酸钠注射液和碳酸钙D₃治疗老年骨质疏松症疗效确切，可有效增加患者BMD，并能明显改善骨代谢和骨转换状态，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Xianling Gubao Capsules combined with Sodium Ibandronate Injection and calcium carbonate D₃ in treatment of osteoporosis. Methods Patients (74 cases) with osteoporosis in Pixian People's Hospital from March 2013 to March 2014 were divided into control and treatment groups according to the different treatments, and each group had 37 cases. The patients in the control group were iv administered with Sodium Ibandronate Injection, 2 mg added to normal saline 250 mL, drip time≥2 h, once 3 months. And they were po administered with Calcium Carbonate D₃ Tablets, 1 tablet/d. The patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of control group, 2 grains/time, three times daily. The patients in two groups were treated for 12 months. After treatment, the clinical efficacy was evaluated, and the changes of S-Ca, S-P, ALP, BMD, and BGP in two groups before and after treatment were compared. Results After treatment, the clinical effect in the control and treatment groups were 78.38% and 89.19%, respectively, and there were differences between two groups (P<0.05). After treatment, S-P and ALP in two groups were significantly decreased, but S-Ca was increased, and the difference was statistically significant in the same group (P<0.05); The observational indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, L2-L4 BMD femoral neck BMD and BGP were significantly increased, and the difference was statistically significant in the same group (P<0.05); And the increase degree of these observational indexes in the treatment group was more significantly than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xianling Gubao Capsules combined with Sodium Ibandronate Injection and calcium carbonate D₃ in treatment of osteoporosis has a good clinical effect, can effectively increase BMD, and improve the bone metabolism and bone turnover status, which has a certain clinical application value.