目的 探讨乌灵胶囊联合艾司西酞普兰和奥氮平治疗抑郁症的临床疗效。方法 收集2012年7月—2015年7月在河南省中医院接受治疗的抑郁症患者86例，随机分为对照组和治疗组，每组各43例。对照组口服草酸艾司西酞普兰片，10mg/d，2周后根据病情可加至20 mg/d；同时口服奥氮平片，5 mg/d。治疗组在对照组基础上口服乌灵胶囊，3粒/次，3次/d。两组患者均连续治疗8周。观察两组的临床疗效，同时比较两组患者治疗前后的HAMD和WHOQOL-BREF评分。结果 治疗后，对照组与治疗组总有效率分别为79.07%和95.35%，两组间差异具有统计学意义（P<0.05）。治疗后，两组患者HAMD评分均降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组降低的更显著，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者生理健康、心理状态、社会关系和周围环境等WHOQOL-BREF评分均较治疗前升高，同组比较差异具有统计学意义（P<0.05）；且治疗组WHOQOL-BREF评分比对照组的升高更明显（P<0.05）。结论 乌灵胶囊联合艾司西酞普兰和奥氮平可有效缓解抑郁症患者抑郁状态，提高生活质量。

Objective To observe the clinical efficacies of Wuling Capsules combined with escitalopram and olanzapine in treatment of depression. Methods Patients (86 cases) with depression in Henan Province Hospital of TCM from July 2012 to July 2015 were enrolled in this study and divided into control and treatment groups, and each group had 43 cases. The patients in the control group were po administered with Escitalopram Oxalate Tablets, 10 mg/d, and the dosage could be added to 20 mg/d according to the specific condition after two weeks. In the same time, the patients were po administered with Olanzapine Tablets, 5 mg/d. The patients in the treatment group were po administered with Wuling Capsules on the basis of control group, 3 grains/time, three times daily. The patients in two groups were treated for 8 weeks. After treatment, clinical efficacy was evaluated, and HAMD and WHOQOL-BREF scores in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 79.07% and 95.35%, respectively, and there was significant difference between groups (P<0.05). After treatment, HAMD scores in two groups were decreased, and the difference was statistically significant in the same group before and after treatment (P<0.05). And the score in the treatment group was lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the WHOQOL-BREF scores of physical health, psychological status, social relations, and surrounding environment in two groups were increased, and the difference was statistically significant in the same group (P<0.05); And WHOQOL-BREF scores in the treatment group were higher than those in the control group (P<0.05). Conclusion Wuling Capsules combined with escitalopram and olanzapine can effectively alleviate the depression states of patients and improve the quality of life.