目的 探讨盐酸小檗碱联合西格列汀治疗肥胖2型糖尿病的临床疗效。方法 选取2014年8月—2015年8月在武安市第一人民医院内分泌科接受治疗的肥胖2型糖尿病患者96例为研究对象，按治疗方案的差别分为对照组和治疗组，每组各48例。对照组口服磷酸西格列汀片，100 mg/次，1次/d。治疗组在对照组基础上口服盐酸小檗碱片，0.3 g/次，3次/d，餐前口服。两组患者均连续治疗12周。观察两组的临床疗效，比较两组患者的血糖指标和炎症指标。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、95.83%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的空腹血糖（FPG）、餐后2 h血糖及糖化血红蛋白（HbA1c）均明显降低，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的C-反应蛋白（CRP）、白细胞介素-6（IL-6）、内皮素-1（ET-1）及血栓素2（TXB2）均显著下降，而前列腺素Fla（PGFla）、一氧化氮（NO）均显著上升，同组治疗前后差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 盐酸小檗碱联合西格列汀治疗肥胖2型糖尿病具有较好的临床疗效，能明显降低患者血糖，改善炎症指标，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of berberine hydrochloride combined with sitagliptin in treatment of diabesity type 2 diabetes mellitus. Methods Patients (96 cases) with diabesity type 2 diabetes mellitus in Department of Endocrinology of Wu'an First People's Hospital from August 2014 to August 2015 were enrolled in this study. According to the different treatment plans, patients were divided into the control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Sitagliptin Phosphate Tablets, 100 mg/time, once daily. Patients in the treatment group were po administered with Berberine Hydrochloride Tablets on the basis of the control group, 0.3 g/time, three times daily. After treatment, the efficacies were evaluated, and blood glucose indexes and inflammation indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 95.83%, respectively, and there was difference between two groups (P<0.05). After treatment, HbA1c, 2hPG, and FPG in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). The observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, CRP, IL-6, TXB2, and ET-1 in two groups were significantly decreased, but PGFla and NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). The observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Berberine hydrochloride combined with sitagliptin has the curative effect in treatment of diabesity type 2 diabetes mellitus, can significantly reduce blood glucose indexes, improve inflammation indexes, which has a certain clinical application value.