目的 探讨连花清瘟胶囊联合特布他林和布地奈德治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法 选取2015年5月—2016年1月在仙桃市中医医院呼吸内科进行治疗的慢性阻塞性肺疾病急性加重期患者80例，按照治疗方法的不同分为对照组和治疗组，每组各40例。对照组给予硫酸特布他林雾化液5 mg联合吸入用布地奈德混悬液1 mg与生理盐水10mL混合后进行雾化吸入，20 min/次，2次/d。治疗组在对照组治疗基础上口服连花清瘟胶囊，4粒/次，3次/d。两组患者均连续治疗14 d。观察两组的临床疗效，同时比较两组喘息、咳嗽、哮鸣音等临床症状改善时间；比较两组患者治疗前后病情积分、一秒用力呼气容积（FEV₁）、用力肺活量（FVC）、FEV₁/FVC、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、IL-8、pH值、血氧分压（pO₂）以及动脉血二氧化碳分压（pCO₂）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为80.0%、95.0%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者喘息缓解时间、咳嗽消失时间、哮鸣音消失时间均显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者病情积分、pCO₂、IL-6、IL-8、TNF-α均显著降低，pH值、pO₂、FEV₁、FVC、FEV₁/FVC均显著升高，同组治疗前后差异有统计学意义（P<0.05），且治疗组这些观察指标的改善程度优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 连花清瘟胶囊联合特布他林和布地奈德治疗慢性阻塞性肺疾病急性加重期具有较好的临床疗效，可明显改善患者的临床症状和肺功能，并可降低机体炎性反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Lianhua Qingwen Capsules combined with terbutaline and budesonide in treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods Patients (80 cases) with acute exacerbation of chronic obstructive pulmonary disease in Traditional Chinese Medicine Hospital of Xiantao from May 2015 to January 2016 were enrolled in this study. According to the different treatment plans, patients were divided into control group (40 cases) and treatment group (40 cases). The patients in the control group were inhal administered with Terbutaline Sulphate Solution for nebulization 5 mg and Budesonide Suspension for inhalation 1 mg added into normal saline 10 mL, 20 mL/time, twice daily. The patients in the treatment group were po administered with Lianhua Qingwen Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, improved time of wheezing, coughing, wheezing sound in two groups were compared. The changes of illness integration, FEV₁, FVC, FEV₁/FVC, TNF-α, IL-6, IL-8, pH value, pO₂, and pCO₂ in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 80.0% and 95.0%, respectively, and there were differences between two groups (P<0.05).After treatment, breathing ease time, coughing disappeared time, and wheezing sound disappeared time in the treatment group were shorter than those in the control group. After treatment, illness integration, pCO₂, IL-6, IL-8, and TNF-α in two groups were significantly decreased, and pH value, pO₂, FEV₁, FVC, and FEV₁/FVC were significantly increased, the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Lianhua Qingwen Capsules combined with terbutaline and budesonide has clinical curative effect in treatment of acute exacerbation of chronic obstructive pulmonary disease, and can obviously improve the clinical symptoms and lung function and reduce the inflammatory response, which has a certain clinical application value.