目的 探讨上海市嘉定区中心医院中药注射剂致不良反应(ADR)发生的成因和特点,为临床合理用药提供参考。方法 对2013－2015年上海市嘉定区中心医院临床上报的65例中药注射剂ADR报告进行统计分析。结果 65例ADR报告中,女性比例略高于男性,年龄主要集中在50~60岁;无过敏史的患者49例,构成比为75.38%;最易引发ADR的药品为血栓通注射液、参麦注射液、骨肽注射液;静脉滴注后1~7 d发生ADR的例数最多;以皮肤及附件损害、全身损伤较为多见,所占构成比分别为61.54%、20.00%;59例(90.77%)与其他药物联合用药。结论 临床应加强中药注射剂ADR的监测与上报工作,以保障合理用药与患者安全。

Objective To explore the causes and characteristics of adverse drug reactions (ADR) caused by traditional Chinese medicine injections in Shanghai Jiading District Central Hospital, and to provide reference for improving clinical rational drug use. Methods ADR reports (65 cases) induced by traditional Chinese medicine injections in Shanghai Jiading District Central Hospital from 2013 to 2015 were analyzed statistically. Results Among ADR reports (65 cases), women with ADR induced by traditional Chinese medicine injections were more than men, and more were focused on 50 - 60 years old. There were 49 cases of patients without history of allergies, accounting for 75.38%. The drugs most easily triggering ADR were Xueshuantong Injection, Shenmai Injection, and Ossotide Injection. The most cases occured during 1 - 7 d after the intravenous drip. The main ADR were skin and its appendages injury (61.54%) and systemic injury (20.00%). There were 59 cases (90.77%) of ADR caused by combination with other drugs. Conclusion More attention should be paid on the ADR monitoring and reporting of traditional Chinese medicine injections to promote clinical rational use and safe medication.