目的 探讨卡前列甲酯栓联合Bakri球囊治疗产后出血的临床疗效。方法 选取2014年6月-2015年6月滨州医学院烟台附属医院收治的产后出血患者90例,随机分为对照组和治疗组,每组各45例。对照组自阴道或剖宫产术中子宫切口处置入1个Bakri球囊,并注入200~300 mL生理盐水,治疗组在对照组基础上从阴道置入1枚卡前列甲酯栓。两组患者均治疗24 h。比较两组患者的临床疗效,收缩压(SBP)、舒张压(DBP)和血氧饱和度(SaO₂)、出血量以及不良反应情况。结果 治疗后,对照组和治疗组的总有效率分别为86.67%、97.78%,两组比较差异有统计学意义(P<0.05)。治疗后,两组的SBP、DBP和SaO₂均较治疗前显著改善,同组治疗前后差异有统计学意义(P<0.05);两组治疗后的SBP、DBP和SaO₂比较差异无统计学意义;治疗2、24 h后,两组出血量均较治疗前明显减少,同组治疗前后差异有统计学意义(P<0.05);且治疗组的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论 卡前列甲酯栓联合Bakri球囊治疗产后出血具有较好的临床疗效,可减少出血量,且安全性较高,具有一定的临床推广应用价值。

Objective To explore clinical efficacy of Carboprost Methylate Suppositories combined with Bakri Balloon in treatment of postpartum hemorrhage. Methods Patients (90 cases) with postpartum hemorrhage in Yantai Affiliated Hospital of Binzhou Medical University from June 2014 to June 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 45 cases. Patients in the control group were given one Bakri Balloon in vagina or uterine incision during caesarean section, and then given 200 - 300 mL normal saline. Patients in the treatment group were given one Carboprost Methylate Suppositories in vagina on the basis of the control group. The patients in two groups were treated for 24 h. After treatment, the clinical efficacy, systolic pressure (SBP), diastolic pressure (DBP), and oxygen saturation (SaO₂), amount of bleeding, and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 86.67% and 97.78%, respectively, and there was difference between two groups (P < 0.05). SBP, DBP, and SaO₂ in two groups were improved, and the differences were statistically significant in the same group (P < 0.05). But there was no significant difference in these observational indexes between two groups. After treatment for 2 and 24 h, amount of bleeding in two groups were decreased and the differences were statistically significant in the same group (P < 0.05). The amount of bleeding in the treatment group was lower than that in the control group, with significant differences between two groups (P < 0.05). There was no significant difference in adverse effects rate between two groups. Conclusion Carboprost Methylate Suppositories combined with Bakri Balloon has good effect in treatment of postpartum hemorrhage, can decrease amount of bleeding with good safety, which has a certain clinical application value.