目的 探究香菊胶囊联合氮卓斯汀治疗过敏性鼻炎的临床疗效。方法 选取2014年8月-2015年8月首都医科大学附属北京潞河医院耳鼻喉科收治的过敏性鼻炎患者216例,根据不同的治疗方案分对照组和治疗组,每组各108例。对照组给予盐酸氮卓斯汀鼻喷雾剂,每侧鼻孔1喷/次,2次/d。治疗组在对照组基础上口服香菊胶囊,3粒/次,3次/d。两组均连续治疗1个月。观察两组的临床疗效,同时比较两组患者的症状评分和血清学指标的情况。结果 治疗后,对照组和治疗组的总有效率分别为85.19%、93.52%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者打喷嚏、流涕、鼻塞、鼻痒及总分均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者IL-12、IFN-γ水平显著升高,而IL-4、IL-10、IgE水平显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论 香菊胶囊联合氮卓斯汀治疗过敏性鼻炎具有较好的临床疗效,可缓解临床症状,提高机体的免疫能力,具有一定临床推广应用价值。

Objective To investigate the effect of Xiangju Capsules combined with azelastine in treatment of allergic rhinitis. Methods Patients (216 cases) with allergic rhinitis in Department of Otolaryngology, Beijing Luhe Hospital Capital Medical University from August 2014 to August 2015 were enrolled into this study. According to the different treatment plans, patients were divided into the control and treatment groups, and each group had 108 cases. Patients in the control group were given Azelastine Hydrochloride Nasal Spray, both nostril 1 spout/time, twice daily. Patients in the treatment group were po administered with Xiangju Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and the changes of symptom scores and serology indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.19% and 93.52%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of sneezing, runny nose, nasal congestion, and nasal itching, and the total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IL-12 and IFN-γ in two groups were significantly increased, but the levels of IL-4, IL-10, and IgE in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiangju Capsules combined with azelastine has clinical curative effect in treatment of allergic rhinitis, and can relieve clinical symptom, improve immune ability, which has a certain clinical application value.