目的 探讨口炎清颗粒联合曲安奈德治疗口腔扁平苔藓的临床疗效。方法 回顾性分析2014年1月-2015年10月在中国医科大学附属口腔医院接受治疗的口腔扁平苔藓患者临床资料78份,随机分为对照组(39例)和治疗组(39例)。所有患者均进行基础治疗以减轻对口腔黏膜的刺激。对照组病灶黏膜基底部注射醋酸曲安奈德注射液,10 mg溶于2%利多卡因2.5 mL中,1次/周。治疗组在对照组基础上口服口炎清颗粒,2袋/次,2次/d。两组患者均连续治疗4周。比较两组的临床疗效,同时比较两组体征评分、疼痛评分和生活质量评分变化,观察两组治疗前后血清IL-2、IL-4和TNF-α水平变化。结果 治疗后,对照组和治疗组的总有效率为84.62%、97.44%,两组比较差异有统计学意义(P<0.05)。治疗后,两组体征评分、疼痛评分和生活质量评分均较同组治疗前降低(P<0.05),且治疗组比对照组降低的更显著(P<0.05)。治疗后两组血清IL-2、IL-4和TNF-α水平均较同组治疗前降低(P<0.05),且治疗组降低的更显著(P<0.05)。结论 口炎清颗粒联合曲安奈德治疗口腔扁平苔藓疗效显著,可明显降低患者血清炎性因子水平,有效改善患者临床症状,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Kouyanqing Granules combined with triamcinolone acetonide in treatment of oral lichen planus. Methods The clinical data of 78 patients with oral lichen planus in China Medical University Stomatology Hospital from January 2014 to October 2015 were retrospectively analyzed, and were randomly divided into control group (39 cases) and treatment group (39 cases). All patients were given basic treatment to reduce the stimulation to oral mucosa. The patients in the control group were injected with Triamcinolone Acetonide Acetate Injection in lesion mucosal basement, 10 mg dissolved in 2% lidocaine 2.5 mL, once a week. The patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 2 bags/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacies in two groups were evaluated. And the changes of scores of physical signs, pain and life quality were compared. In the same time, the levels of serum IL-2, IL-4, and TNF-α in two groups before and after treatment were determined. Results After treatment, the total efficacies in the control group and treatment group were 84.62% and 97.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of physical signs, pain and life quality in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of serum IL-2, IL-4, and TNF-α in two groups weresignificantly decreased (P < 0.05), and the reductions in treatment group were more obvious, with significant difference between two groups (P < 0.05). Conclusion Kouyanqing Granules combined with triamcinolone acetonide has a significant curative effect in treatment of oral lichen planus, can significantly decrease the levels of serum inflammatory cytokines, and effectively improve clinical symptoms, which has a certain clinical application value.