目的 观察布拉酵母菌联合舒肝宁注射液治疗新生儿高胆红素血症的临床疗效。方法 选取2014年6月-2015年6月在湖北医药学院附属人民医院进行治疗的新生儿高胆红素血症的患儿70例,随机分为对照组和治疗组,每组各35例。对照组患儿静脉滴注舒肝宁注射液,10 mL加入到10%葡萄糖注射液250 mL,1次/d,症状缓解后可改用肌内注射2 mL/次,1次/d。治疗组患儿在对照组的基础上给予布拉氏酵母菌散,1袋/次,1次/d。两组患儿均治疗2周。观察两组患儿的临床疗效,同时比较两组治疗前后胆红素水平和常见临床指标的变化。结果 治疗后,对照组和治疗组的总有效率分别为80.00%、94.29%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿血清胆红素水平和经皮测定胆红素水平均显著下降,同组治疗前后差异比较具有统计学意义(P<0.05);且治疗后治疗组这些观察指标的下降幅度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患儿日均胆红素下降值明显大于对照组,而黄疸消退时间和蓝光治疗时间明显短于对照组,两组这些观察指标比较差异具有统计学意义(P<0.05)。结论 布拉氏酵母菌联合舒肝宁注射液治疗新生儿高胆红素血症具有较好的临床疗效,可显著降低患儿体内胆红素水平,缩短黄疸消退时间及蓝光治疗时间,具有一定的临床推广应用价值。

Objective To understand the distribution and drug resistance analysis of pathogenic bacteria causing lower respiratory tract infection in Second Affiliated Hospital of Tianjin University of TCM, and to provide reference for clinical rational drug use. Methods The distribution and drug resistance analysis of pathogenic bacteria causing lower respiratory tract infection in Second Affiliated Hospital of Tianjin University of TCM in 2015 were analyzed retrospectively. Results Total 662 strains of pathogens were isolated, in which Gram-negative bacteria were 504 strains (76.13%). Gram-positive bacteria (60 strains) accounted for 9.06%. While there were also 98 strains of fungus (14.80%) isolated. The sensitive rate of main Gram-negative bacteria against meropenem was above 82%. Different bacteria had different sensitive rates against the same antibacterial drug. And Gram-negative bacteria and Gram-negative bacteria generally had the phenomenon of multiple drug resistance. The sensitive rates of Candida albicans against amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, and voriconazole were above 98%. Conclusion The main pathogens causing lower respiratory tract infection is Gram-negative bacteria. The different drug resistance exists in different kinds of bacteria. The physician should understand local pathogenic bacteria distribution and drug resistance timely, in order to guide the clinical empirical use of antibacterial drugs.