目的 探究参附注射液联合静注人免疫球蛋白治疗川崎病的临床疗效。方法 选取2013年5月-2015年5月重庆市垫江县人民医院收治的川崎病患儿128例,随机分为对照组和治疗组,每组各64例。两组患儿均给予常规治疗,对照组在常规治疗的基础上静脉滴注静注人免疫球蛋白(pH 4),2 g/kg,1次输注;治疗组在对照组的基础上静脉滴注参附注射液,4 mL加到5%葡萄糖溶液100 mL,1次/d。两组患儿均治疗15 d。治疗后,观察两组的临床疗效,同时比较两组血常规、退热时间、住院时间、红细胞沉降率以及C反应蛋白变化情况。结果 治疗后,对照组和治疗组的总有效率分别为76.6%、92.2%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿的白细胞明显降低,而血小板和血红蛋白均明显升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组治疗后这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组退热时间和住院时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿的红细胞沉降率和C-反应蛋白均显著下降,同组治疗前后差异有无统计学意义(P>0.05);且治疗组治疗后这些观察指标改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 参附注射液联合静注人免疫球蛋白治疗川崎病具有较好的临床疗效,能改善患儿血液学指标,缩短住院时间,具有一定的临床推广应用价值。

Objective To explore clinical efficacy of Carboprost Methylate Suppositories combined with Bakri Balloon in treatment of postpartum hemorrhage. Methods Patients (90 cases) with postpartum hemorrhage in Yantai Affiliated Hospital of Binzhou Medical University from June 2014 to June 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 45 cases. Patients in the control group were given one Bakri Balloon in vagina or uterine incision during caesarean section, and then given 200 - 300 mL normal saline. Patients in the treatment group were given one Carboprost Methylate Suppositories in vagina on the basis of the control group. The patients in two groups were treated for 24 h. After treatment, the clinical efficacy, systolic pressure (SBP), diastolic pressure (DBP), and oxygen saturation (SaO₂), amount of bleeding, and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 86.67% and 97.78%, respectively, and there was difference between two groups (P < 0.05). SBP, DBP, and SaO₂ in two groups were improved, and the differences were statistically significant in the same group (P < 0.05). But there was no significant difference in these observational indexes between two groups. After treatment for 2 and 24 h, amount of bleeding in two groups were decreased and the differences were statistically significant in the same group (P < 0.05). The amount of bleeding in the treatment group was lower than that in the control group, with significant differences between two groups (P < 0.05). There was no significant difference in adverse effects rate between two groups. Conclusion Carboprost Methylate Suppositories combined with Bakri Balloon has good effect in treatment of postpartum hemorrhage, can decrease amount of bleeding with good safety, which has a certain clinical application value.