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[摘要]
目的 观察金钱草颗粒治疗术后肾结石的临床疗效。方法 选取北京市顺义区医院于2013年4月-2015年1月就诊的肾结石患者86例,按随机数字表格法将患者分为对照组和治疗组,每组各43例。对照组经肾镜输尿管镜联合三代气压弹道碎石术治疗,术后常规处理。治疗组在对照组基础上口服金钱草颗粒,1袋/次,2次/d。两组均连续治疗4周。观察两组的临床疗效,同时比较两组实验室指标、中医证候总积分和复发情况。结果 治疗后,对照组和治疗组的总有效率分别为76.74%、93.02%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组pH值明显上升,24h尿酸、24h尿钙水平显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组中医证候总积分均明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组该指标的下降程度明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组随访6、12个月结石复发率均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 金钱草颗粒治疗术后肾结石具有较好的临床疗效,显著减少结石复发,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the effect of Jinqiancao Granules in treatment of postoperative kidney calculus. Methods Patients (86 cases) with kidney calculus in Beijing Shunyi District Hospital from April 2013 to January 2015 were divided into control and treatment groups according to the random number table method, and each group had 43 cases. The patients in the control group were underwent renal endoscopy combined with three generations of pneumatic lithotripsy, and given routine treatment after operation. The patients in the treatment group were po administered with Jinqiancao Granules on the basis of control group, 1 bag/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and laboratory related indexes, total scores of TCM syndrome, and calculi recurrence rate in the two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there were differences between two groups (P< 0.05). After treatment, pH values in two groups were significantly increased, levels of 24 h uric acid and 24 h urinary calcium in two groups were significantly decreased, and the differences were statistically significant in the same group (P< 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P< 0.05). After treatment, total scores of TCM syndrome in the two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). These observational indexes in treatment group were lower than those in control group, with significant difference between two groups (P< 0.05). Recurrence rates of 6 months and 12 months in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Jinqiancao Granules has clinical curative effect in treatment of postoperative kidney calculus, and can significantly reduce the recurrence rate of kidney calculus, which has a certain clinical application value.
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