[关键词]
[摘要]
目的 探讨肿痛安胶囊联合盐酸米诺环素治疗智齿冠周炎的临床疗效。方法 选取2015年1月-2016年1月上海市奉贤区奉城医院收治的智齿冠周炎患者106例,随机分为对照组和治疗组,每组各53例。对照组给予盐酸米诺环素软膏,置入牙周袋中,直至部分溢出为止,1次/d。治疗组在对照组治疗的基础上口服肿痛安胶囊,2粒/次,3次/d。两组患者均连续治疗5d。观察两组的临床疗效,同时比较两组治疗前后革兰氏染色情况、牙龈指数(GI)、疼痛缓解情况。结果 治疗后,对照组和治疗组的总有效率分别为84.91%、96.23%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者细菌密度、螺旋体、G-菌、GI均显著降低,G+菌显著升高,同组治疗前后差异具有统计学意义(P<0.05);且与对照组相比,治疗组这些指标的改善程度更显著,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者疼痛0级人数显著增加,疼痛1、2、3级人数显著减少,同组治疗前后差异具有统计学意义(P<0.05);治疗后,治疗组疼痛0级人数多于对照组,2级人数显著少于对照组,两组比较差异有统计学意义(P<0.05)。结论 肿痛安胶囊联合盐酸米诺环素治疗智齿冠周炎具有很好的临床效果,能改善盲袋内革兰氏染色情况,缓解患者疼痛,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Zhongtong'an Capsules combined with minocycline hydrochloride in treatment of wisdom tooth pericoronitis. Methods Patients (106 cases) with wisdom tooth pericoronitis in Fengxian Hospital of Fengxian District in Shanghai from January 2015 to January 2016 were randomly divided into the control and treatment groups, and each group had 53 cases. Patients in the control group were given Minocycline Hydrochloride Ointment in periodontal pocket until some overflow, once daily. The patients in the treatment group were po administered with Zhongtong'an Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and Gram's staining, GI, and relief situation of pain in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.91%and 96.23%, respectively, and there were differences between two groups (P < 0.05). After treatment, bacterial density, helix, G-, and GI were significantly reduced, G+ was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, patients in two groups of pain level 0 were significant increased, and patients of pain level 1, 2, and 3 was significantly reduced, and the difference was statistically significant in the same group (P < 0.05). After treatment, patients in treatment group of pain level 0 were more than those in the control group, and patients of pain level 2 were less than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Zhongtong'an Capsules combined with minocycline hydrochloride has clinical curative effect in treatment of wisdom tooth pericoronitis, and can improve the gram staining of blind bag, and also relieve the pain of patients, which has a certain clinical application value.
[中图分类号]
[基金项目]