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[摘要]
目的 探究致康胶囊联合兰索拉唑治疗十二指肠溃疡出血的疗效观察。方法 选取2012年4月-2015年4月内江市第二人民医院收治的十二指肠溃疡出血患者98例,按治疗方案不同分为对照组和治疗组,每组各49例。对照组静脉滴注注射用兰索拉唑,30mg溶于100mL0.9%氯化钠溶液中,1次/d。治疗组在对照组基础上口服致康胶囊,2粒/次,3次/d。两组患者均治疗14d。观察两组的临床疗效,同时比较两组患者止血效果、腹痛消失时间及不良反应情况。结果 治疗后,对照组和治疗组的总有效率分别为81.63%、95.92%,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的72h止血率分别为75.51%、91.84%,两组比较差异有统计学意义(P<0.05)。治疗组止血时间和腹痛消失时间均比对照组缩短,两组比较差异有统计学意义(P<0.05)。对照组和治疗组的不良反应发生率分别为8.16%、6.12%,两组比较差异无统计学意义。结论 致康胶囊联合兰索拉唑治疗十二指肠溃疡出血具有较好的临床疗效,能缩短止血时间,不良反应少,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical efficacy of Zhikang Capsules combined with lansoprazol in treatment of duodenal ulcer bleeding. Methods Patients (98 cases) with duodenal ulcer bleeding in the Second People's Hospital of Neijiang from April 2012 to April 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control and treatment groups, and each group had 49 cases. The patients in the control group were iv administered with Lansoprazole for Injection, 30 mg added into 100 mL normal saline, once daily. The patients in the treatment group were po administered with Zhikang Capsules on the basis of control group, 2 grains/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies in two groups were evaluated, and the hemostatic effect, abdominal pain disappearance time, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.63% and 95.92%, respectively, and there was difference between two groups (P < 0.05). After treatment, the 72 h hemostatic rate in the control and treatment groups were 75.51% and 91.84%, respectively, and there was difference between two groups (P < 0.05). The hemostatic time and abdominal pain disappearance time in the treatment group were shorter than those in the control group, and there were differences between two groups (P < 0.05). The incidence of adverse reactions in the control and treatment groups were 8.16% and 6.12%, respectively, and there was no difference between two groups. Conclusion Zhikang Capsules combined with lansoprazole has clinical curative effect in treatment of duodenal ulcer bleeding, and can shorten hemostatic time, lessen adverse reactions, which has a certain clinical application value.
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