目的 探讨乌梅丸联合5-氨基水杨酸治疗溃疡性结肠炎的临床疗效。方法 选取2014年3月-2015年7月仙桃市中医医院消化内科收治的溃疡性结肠炎患者76例,按治疗方法不同分为对照组和治疗组,每组各38例。对照组口服5-氨基水杨酸肠溶片,2片/次,3次/d。治疗组在对照组治疗基础上口服乌梅丸,6丸/次,3次/d。两组患者均连续治疗6周。观察两组的临床疗效,比较治疗前后两组中医症状评分、血清炎性因子包括IL-6、IL-8、IL-10、TNF-α水平变化,同时比较两组肠道菌群的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为78.95%、94.74%,两组比较差异有统计学意义(P<0.05)。两组患者中医症状评分、IL-6、IL-8及TNF-α均降低,IL-10显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者双歧杆菌和乳酸菌均显著升高,大肠杆菌显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 乌梅丸联合5-氨基水杨酸肠溶片治疗溃疡性结肠炎具有较好的临床疗效,可降低患者临床中医症状评分,改善血清炎症细胞因子水平,促进肠道菌群恢复,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Wumei Pills combined with 5-aminosalicylic acid in treatment of ulcerative colitis. Methods Patients (76 cases) with ulcerative colitis in Traditional Chinese Medicine Hospital of Xiantao from March 2014 to July 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control group (38 cases) and treatment group (38 cases). The patients in the control group were po administered with 5-Aminosalicylic Acid Enteric Tables, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Wumei Pills on the basis of control group, 6 pills/time, three times daily. The patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and the changes of syndrome scores, serum inflammatory factors including IL-6, IL-8, IL-10, and TNF-α, and intestinal flora before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 78.95% and 94.74%, respectively, and there were differences between two groups (P < 0.05). After treatment, syndrome scores, IL-6, IL-8, and TNF-α in two groups were significantly decreased, and IL-10 was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, bifidobacteria and lactobacillus in two groups were significantly increased, and E.coli was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Wumei Pills combined with 5-aminosalicylic acid has clinical curative effect in treatment of ulcerative colitis, and can decrease the clinical symptom scores, and can improve the serum levels of inflammatory cytokines, also can promote the intestinal flora restore, which has a certain clinical application value.