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[摘要]
目的 探讨舒血宁注射液联合盐酸替扎尼定治疗椎动脉型颈椎病的临床疗效。方法 选取2015年1月-2016年1月遂宁市中心医院收治的椎动脉型颈椎病患者72例,根据治疗方案的不同分为对照组和治疗组,每组各36例。对照组口服盐酸替扎尼定片,2mg/次,3次/d。治疗组在对照组基础上静脉滴注舒血宁注射液,20mL用5%葡萄糖溶液稀释至250mL,1次/d。两组患者均连续治疗28d。观察两组的临床疗效,同时比较治疗前后两组患者的临床症状评分、HAD评分、NRS评分、WHOQOL-BREF评分及生理应激指标的变化。结果 治疗后,对照组和治疗组的总有效率分别为77.78%、94.44%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者临床症状评分、HAD评分和NRS评分均较治疗前显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者生理健康、心理状态、社会关系及周围环境评分均较治疗前升高,同组治疗前后差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组空腹血糖均较治疗前降低,而餐后胰岛素水平均较治疗前升高,同组治疗前后差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 舒血宁注射液联合盐酸替扎尼定片治疗椎动脉型颈椎病具有较好的临床疗效,可提高患者生活质量,改善患者生理应激状态,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Shuxuening Injection combined with Tizanidine Hydrochloride Tablets in treatment of cervical spondylosis of vertebral artery type. Methods Patients (72 cases) with cervical spondylosis of vertebral artery type in Suining Central Hospital from January 2015 to January 2016 were enrolled in this study. According to the different treatment plans, patients were divided into control and treatment groups, and each group had 36 cases. Patients in the control group were po administered with Tizanidine Hydrochloride Tablets, 2 mg/time, three times daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 20 mL was diluted with 5% glucose into 250 mL, once daily. Patients in two groups were treated for 28 d. After treatment, the efficacy was evaluated, and the scores of clinical symptoms, HAD, NRS, and WHOQOL-BREF, and physiological stress indexes were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 94.44%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of clinical symptoms, HAD, and NRS in two groups were significantly increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of physiological health, psychological state, social relationship, and surrounding environment in two groups were increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the blood glucose levels in two groups were decreased, but the insulin levels in two groups were increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between groups (P < 0.05). Conclusion Shuxuening Injection combined with Tizanidine Hydrochloride Tablets has clinical curative effect in treatment of cervical spondylosis of vertebral artery type, and can improve the quality of life, and the state of physiological stress, which has a certain clinical application value.
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