目的 探讨热毒宁注射液联合阿奇霉素和细辛脑注射液治疗支原体肺炎的临床疗效。方法 收集2012年3月-2015年3月晋州市人民医院儿科接受治疗的支原体肺炎患者150例,按照治疗方法的不同分为对照组和治疗组,每组各75例。对照组口服阿奇霉素干混悬剂,第1天10mg/kg,第2天~第7天5mg/kg,停药3d后按5mg/kg服用4d;同时静脉滴注细辛脑注射液,0.5mg/kg加入5%葡萄糖溶液250mL,1次/d。治疗组在对照组治疗基础上静脉滴注热毒宁注射液,0.5mL/kg加入5%葡萄糖溶液250mL,1次/d。两组患者均连续治疗2周。观察两组的临床疗效,同时比较两组体温恢复时间、咳嗽消失时间和肺部啰音消失时间。比较两组治疗前后白细胞介素6(IL-6)、IL-8、肿瘤坏死因子α(TNF-α)及C反应蛋白(CRP)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为89.33%、97.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组体温恢复时间、咳嗽消失时间、肺部啰音消失时间均显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者血清IL-6、IL-8、TNF-α、CRP均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 热毒宁注射液联合阿奇霉素和细辛脑注射液治疗支原体肺炎具有较好的临床疗效,可明显改善患者的临床症状,降低血清炎性因子水平,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Reduning Injection combined with azithromycin and Asarone Injection in treatment of mycoplasma pneumonia. Methods Patients (150 cases) with mycoplasma pneumonia in Department of Pediatrics of Jinzhou People's Hospital from march 2012 to March 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control group (75 cases) and treatment group (75 cases). The patients in the control group were po administered with Azithromycin for Suspension, 10 mg/kg on day 1, 5 mg/kg from day 2 to the day 17, and the dosage was 5 mg/kg for 4 d after 3 d of discontinuation. The patients in the control group were iv administered with Asarone Injection, 0.5 mg/kg added into 5% glucose solution 250 mL, once daily. The patients in the treatment group were iv administered with Reduning Injection on the basis of the control group, 0.5 mL/kg added into 5% glucose solution 250 mL, once daily. The patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the body temperature recovery time, cough disappeared time and lung rale disappeared time in two groups were compared. The changes of IL-6, IL-8, TNF-α, and CRP in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 89.33% and 97.33%, respectively, and there were differences between two groups (P < 0.05). The body temperature recovery time, cough disappeared time and lung rale disappeared time in the treatment group were statistically shorter than those in the control group, and there were differences between two groups (P < 0.05). After treatment, IL-6, IL-8, TNF-α, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Reduning Injection combined with azithromycin and Asarone Injection has clinical curative effect in treatment of mycoplasma pneumonia, and can obviously improve the clinical symptoms, and can reduce the levels of serum inflammatory factors, which has a certain clinical application value.