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[摘要]
目的 探讨喘可治注射液联合细辛脑注射液治疗小儿毛细支气管炎的临床疗效。方法 选取2014年9月-2015年9月在深圳市儿童医院接受治疗的小儿毛细支气管炎患儿94例,按治疗方法的不同分为对照组和治疗组,每组各47例。对照组静脉滴注细辛脑注射液,0.5mg/kg加入5%葡萄糖溶液250mL,2次/d。治疗组在对照组基础上雾化吸入喘可治注射液,2mL与3mL生理盐水混合,2次/d。两组患儿连续治疗7d。观察两组的临床疗效,同时比较两组患儿临床症状、肺功能、炎症变化。结果 治疗后,对照组和治疗组的总有效率分别为82.98%、95.74%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组喘息消失时间、咳嗽消失时间、肺部啰音消失时间和痰鸣音消失时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿RR(呼吸频率)和吸气时间/总呼吸时间(Ti/Tt)均明显降低,而潮气量(TV)、潮气呼气峰流速(PTEF)及达峰时间比(tPTEF/tE)均明显升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿血清IL-10水平均明显降低,而IL-12水平明显升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿气道细胞总数、淋巴细胞、嗜酸性粒细胞和中性粒细胞水平均明显降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 喘可治注射液联合细辛脑注射液治疗小儿支气管炎的临床疗效较好,能明显改善患儿的临床症状、肺功能及炎症状态,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Chuankezhi Injection combined with Asarone Injection in treatment of bronchiolitis in children. Methods Children (94 cases) with bronchiolitis in Shenzhen Children's Hospital from September 2014 to September 2015 were randomly were enrolled in this study. According to the different treatment plan, patients were divided into the control and treatment groups, and each group had 47 cases. Children in the control group were iv administered with Asarone Injection, 0.5 mg/kg added into 5% glucose 250 mL, twice daily. Children in the treatment group were aerosol inhalation administered with Chuankezhi Injection on the basis of control group, 2 mL mixed with normal saline 3 mL, twice daily. Children in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and the changes of clinical symptoms, lung function, and inflammation were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.98% and 95.74%, respectively, and there was difference between two groups (P < 0.05). After treatment, the disappearance time of wheezing, cough, pulmonary rales, and wheezy phlegm in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the RR and Ti/Tt in two groups were significantly decreased, but the TV, PTEF, and tPTEF/tE in two groups were significantly increased, and the differences were statistically significant in the same group (P< 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the levels of IL-10 in two groups were significantly decreased, but the levels of IL-12 in two groups were significantly increased, and the differences were statistically significant in the same group (P< 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the inflammatory cell, leukomonocyte, eosinophile granulocyte, and neutrophile granulocyte at airway in two groups were significantly decreased, and the differences were statistically significant in the same group (P< 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Chuankezhi Injection combined with Asarone Injection has clinical curative effect in treatment of bronchiolitis in children, and can obviously improve the clinical symptoms, lung function, and inflammatory state, which has a certain clinical application value.
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