目的 对2009-2015年凉山州第二人民医院鲍曼不动杆菌的耐药性与抗菌药物用量的相关性进行分析,促进临床合理用药。方法 统计2009-2015年凉山州第二人民医院检验科鲍曼不动杆菌的分布及耐药性和抗菌药物的使用情况,并对鲍曼不动杆菌的耐药性与抗菌药物用量的相关性进行统计分析。结果 共分离出鲍曼不动杆菌2 719株,主要来源为痰液(75.62%),分离株数逐年增加。鲍曼不动杆菌对各类抗菌药物的耐药率均呈上升趋势,对左氧氟沙星耐药率的上升程度最大。对哌拉西林他唑巴坦、左氧氟沙星、替卡西林、头孢他啶、头孢吡肟的耐药率均接近50%。鲍曼不动杆菌对哌拉西林他唑巴坦、头孢他啶、头孢吡肟、左氧氟沙星和米诺环素的耐药率与左氧氟沙星的使用强度呈显著的正相关性。结论 合理使用抗菌药物对于降低鲍曼不动杆菌的耐药性具有重要意义,应根据药物半衰期和药敏试验制定恰当的给药方案。

Objective To analyze the correlation between drug resistance of Acinetobacter baumanniiand dose of antibiotics in The Second People's Hospital of Liangshan Prefecture from 2009 to 2015, and to promote rational drug use in clinic.Methods The distribution and drug resistance of A.baumannii, and the usage of antibiotics in Department of Pharmacy in The Second People's Hospital of Liangshan Prefecture from 2009 to 2015. The correlation between drug resistance of A.baumannii and dose of antibiotics were analyzed.Results Total 2 719 strains of A.baumannii were isolated, and the pathogenic bacteria (75.62%) was isolated mainly from sputum samples. The isolated strains of A.baumannii increased year by year. The drug resistance rate of A.baumanniiagainst various kinds of antibacterial drugs was on the rise, and the drug resistance rate against levofloxacin increased the most. The drug resistance rate of A.baumanniiagainst piperacillin/tazobactam, levofloxacin, ticarcillin, ceftazidime, and cefepime were almost 50%. The resistance rates of A.baumannii against piperacillin/tazobactam, ceftazidime, cefepime, levofloxacin, and minocyline had significantly positive correlation with use density of levofloxacin.Conclusion It is of great significance to rational use antimicrobial drugs to reduce the drug resistance rate of A.baumannii. The appropriate dosage regimen should be made based on the half-life of drugs and drug sensitivity test.