目的 探讨乳酸左氧氟沙星片联合三联疗法治疗幽门螺旋杆菌相关性胃溃疡的疗效。方法 选取2014年6月-2015年6月辽宁省人民医院收治的胃溃疡患者134例,随机分为对照组和治疗组,每组各67例。对照组采用三联疗法,治疗组在对照组的基础上第6天起口服乳酸左氧氟沙星片200 mg,1次/d。两组共治疗10 d。观察两组的幽门螺旋杆菌根除率和临床疗效,比较治疗前后两组血清炎症因子水平和不良反应发生率。结果 治疗后,治疗组的幽门螺旋杆菌根除率为83.6%,显著高于对照组的52.2%,对照组和治疗组的总有效率分别为79.1%、94.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者白细胞介素-6(IL-6)、白细胞介素-17(IL-17)水平均较治疗前显著降低,干扰素-γ(IFN-γ)水平显著升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。两组不良反应发生率比较无统计学意义。结论 乳酸左氧氟沙星片联合三联疗法治疗幽门螺旋杆菌相关性胃溃疡具有较好的疗效,优于单独应用三联疗法,能提高总有效率,降低炎症反应,安全有效,值得在临床中推广使用。

Objective To study the efficacy of Levofloxacin Lactate Tablets combined with triple therapy in treatment of Helicobacter pylori associated gastric ulcer.Methods Patients (134 cases) with H. pylori associated gastric ulcer in The People's Hospital of Liaoning Province from June 2014 to Jun 2015 were randomly divided into control (n= 67 ) and treatment (n= 67 ) groups. Patients in the control group were treated with triple therapy, and the patients in the treatment group were poadministered with Levofloxacin Lactate Tablets from 6th day on the basis of the control group, 200 mg/time, once daily. The patients in two groups were treated for 10 d. After treatment, the efficacy and H.pylori eradication rate were evaluated, and inflammatory factors in serum and incidence rate of adverse reaction in two groups were compared.Results After treatment, H. pylori eradication rate in the treatment group (83.6%) was higher than that (52.2%) of the control group, and the efficacies in the control and treatment groups were 79.1% and 94.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, levels of IL-6 and IL-17 in serum in two groups were significantly decreased, but that of IFN-γ were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). There was no difference of incidence rate of adverse reaction between two groups.Conclusions Levofloxacin Lactate Tablets combined with triple therapy has clinical curative effect in treatment ofH. pylori associated gastric ulcer, has better efficacy than the single triple therapy, and can significantly reduce the inflammatory reaction with less increase in adverse reactions, which has a certain clinical application value.