目的 探讨鼻舒适片联合枸地氯雷他定治疗过敏性鼻炎的临床疗效。方法 选取2015年1月-2016年1月西安交通大学第一附属医院接受治疗的过敏性鼻炎患者138例,随机分为对照组和治疗组,每组各69例。对照组口服枸地氯雷他定胶囊,1粒/次,1次/d。治疗组在对照组的治疗基础上口服鼻舒适片,5片/次,3次/d。两组均连续治疗12 d。观察两组的临床疗效,同时比较两组治疗前后症状积分、白三烯B4(LTB4)、IL-4、IL-10、IL-12、转化生长因子α(TGF-α)、γ-干扰素(IFN-γ)、IgE的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为85.51%、95.65%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者症状(包括鼻塞、鼻痒、喷嚏、流涕)评分、总分、IL-4、IL-10、TGF-α、LTB4、IgE水平均显著降低,IL-12、IFN-γ水平显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 鼻舒适片联合枸地氯雷他定治疗过敏性鼻炎具有较好的临床疗效,可改善患者的临床症状,改善各检测因子水平,具有一定的临床推广应用价值

Objective To explore the clinical efficacy of Bishushi Tablets combined with desloratadine citrate disodium in treatment of allergic rhinitis.Methods Patients (138 cases) with allergic rhinitis in the First Affiliated Hospital of Xi'an Jiaotong University from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 69 cases. The patients in the control group were poadministered with Desloratadine Citrate Disodium Capsules, 1 grain/time, once daily. The patients in the treatment group were poadministered with Bishushi Tablets on the basis of the control group, 5 tablets/time, three times daily. The patients in two groups were treated for 12 d. After treatment, the efficacy was evaluated, and the changes of symptom scores, LTB4, IL-4, IL-10, IL-12, TGF-α, IFN-γ, and IgE in two groups before and after treatment were compared.Results After treatment, the efficacies in the control and treatment groups were 85.51% and 95.65%, respectively, and there were differences between two groups (P < 0.05). After treatment, symptom (including stuffy nose, nasal itching, sneezing, and runny nose) scores, total scores, IL-4, IL-10, TGF-α, LTB4, and IgE in two groups were significantly decreased, IL-12 and IFN-γ were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Bishushi Tablets combined with desloratadine citrate disodium has clinical curative effect in treatment of allergic rhinitis, and can improve the clinical symptoms, also can improve the detection factor levels, which has a certain clinical application value.